The advantage of using gene regulatory networks to link genes based on their interaction at the transcriptional level is that it allows detecting hub genes that could be candidate genes for modulation to revert the disease phenotype and bring the mutant network closer to the healthy one. As a pr...
A–D, I Immunolabeling performed with: the AT8 antibody detecting Ser202-phosphorylated tau protein; E–G, J the PHF1 antibody targeting the double (Ser396/Ser404)-phosphorylated tau protein; K the monoclonal MC1 antibody directed against the conformational epitopes formed by amino acids 7–9 ...
This regulation of the RRP may reflect activity-dependent bulk endocytosis54 during periods of high-frequency firing, which preNMDARs are particularly well suited at detecting because of their dual sensitivity to voltage and to glutamate.34,35,36 In agreement, we found that preNMDARs and local ...
Of these proteins, LFA-1 stands out for being especially attuned to detecting and delivering forces. As with other integrins, LFA-1 occupies multiple conformational states26, each of which exhibits a distinct affinity for its ligands, the intracellular adhesion molecules (ICAM) 1 and 2. In its ...
(Phase 2). To clarify the changes in PSD composition in Phase 2, we next extracted proteins that showed significant changes. Given the difficulty in detecting statistical significance due to the limited sample size (n = 2), we focused proteins that showed >2-fold changes of average ...
Human immunodeficiency virus type 1 (HIV-1) persists lifelong in infected individuals and has evolved unique strategies in order to evade the immune system. One of these strategies is the direct cell-to-cell spread of HIV-1. The formation of a virologica
Of these proteins, LFA-1 stands out for being especially attuned to detecting and delivering forces. As with other integrins, LFA-1 occupies multiple conformational states26, each of which exhibits a distinct affinity for its ligands, the intracellular adhesion molecules (ICAM) 1 and 2. In its...
Though, at the age of 8 months no significant differences in gephyrin expression levels between APPPS1 and WT mice are detectable (B), using three different antibodies: p-Geph (detecting gephyrin phosphorylated at Ser270), Geph1, and Geph2. Student's t-test was used. Data are given as ...
Detecting pro-inflammatory changes in the brain after NP exposure was not altogether surprising as neuroinflammation was previously shown to be induced in both SiO2-NPs-exposed immortalized microglial cell cultures [47] and in the hippocampus after 7 days of SiO2-NPs exposure via intranasal instillatio...
WO/2006/079152 August, 2006 METHOD AND APPARATUS FOR DETECTING INEFFECTIVE INSPIRATORY EFFORTS AND IMPROVING PATIENT-VENTILATOR INTERACTION WO/2006/083675 August, 2006 A STIMULATING DEVICE WO/2006/088696 August, 2006 IMPLANTABLE GENERATING SYSTEM WO/2006/121447 November, 2006 THERAPEUTIC ASSEMBLY WO/2006...