high possibility of progression to liver failure and mortality. In current daily practice, however, the diagnosis of PBC can be determined at very early stage with the elevation of cholestatic enzymes and detectable anti-mitochondrial antibodies (AMA). Progression to cirrhosis can be avoided in most...
Limiting the study to females reduces the confounding influence of gender difference on gastrointestinal function and the gut microbiome. To determine suitability for inclusion as a participant or as a healthy control, initial screening will be conducted via a survey hosted on Research Electronic Data...
Maternal prenatal depression is associated with increased likelihood of neurodevelopmental and psychiatric conditions in offspring. The relationship between maternal depression and offspring outcome may be mediated by in-utero changes in brain development. Recent advances in magnetic resonance imaging (MRI) ha...
73 females with RA were compared to 50 controls using Female Sexual Function Index (FSFI), Core Lower Urinary Tract Symptoms Score (CLSS), Core Lower Urinary Tract Symptoms -Quality of Life Score (CLSS-Q), Hospital Anxiety and Depression Scale (HADS) and a global question for overall relat...
Birmingham is the second most populous city in Britain with a high degree of cultural and religious diversity and ranked the third most deprived city in England [21, 22]. A breakdown of the population profile of gender, age range and ethnicity for both the intervention and control areas is ...
Both education and household income levels are independently associated with the prevalence of depressive symptoms, with household income levels showing a more robust association with depressive symptoms than education levels. This suggests that a high household income level may offset the risk of depressi...
Hyperandrogenism symptoms are prominent in females and include mild hirsutism on the face, scalp hair thinning, acne, and irregular menstrual periods. Males may also have acne.9 Cushing syndrome is also associated with high cortisol levels, resulting in: ...
In addition, previous local community based studies have shown relatively high rates of participants endorsing at least one psychotic symptom (13.9%) [31], being able to tease out the burden of psychotic symptoms attributable to khat use as compared to other risk factors is key to understanding ...
b: Mice undergoing withdrawal showed increased fecal boli and all doses of Org27569 reduced fecal boli in females (but not males) irrespective of whether mice were undergoing withdrawal. c: Mice undergoing withdrawal showed increased body weight loss and Org27569 had no effect on body weight ...
Severe infection and sepsis are medical emergencies. High morbidity and mortality are linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and multiple organ dysfunction. Males appear to have a higher risk of mortality than females. Currently, there are few or no effective...