Fragile X syndrome (FXS) is a neurodevelopmental disorder that is caused by the loss of Fragile X-linked mental retardation protein (FMRP), an RNA binding protein that can bind and recognize different RNA structures and regulate the target mRNAs' translation involved in neuronal synaptic plasticity...
aexpression of wild-type FMRP, but not FMRP(I304N) or FMRPΔRGG, restored synaptic scaling [translate] a我的钥匙呢,我记不起来放哪去了。 My key, which couldn't I record put go. [translate] apossibility that at least some of the symptoms of Fragile-X syndrome reflect impaired ...
Fragile X syndrome is the most common form of inherited intellectual disability (learning disabilities and cognitive impairment)1. Usually, males are more severely affected by this disorder than females. Affected individuals usually have delayed development of speech and language by age 22. Most males ...
There was a trend for an age-related difference in disruptive behavior. Findings add to understanding of the developmental trajectory of ASD symptoms in adulthood. 展开 关键词: Fragile X syndrome Autism DSM Adult Aging DOI: 10.1007/s10803-015-2513-7 年份: 2015 ...
No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic ...
We used survey methodology to assess parent-reported autism symptomology in 758 individuals (639 males; 119 females) with fragile X syndrome (FXS). Caregivers reported whether their child with FXS had been diagnosed with an autism spectrum disorder (ASD) and endorsed symptoms based on a list of...
Fragile X syndrome is the most common cause of autism. Even though the single gene that's responsible for it was discovered in 1991, and the disease is detected by a simple blood test, there's no treatment or cure. A team of researchers led by Michigan State University, however, has pro...
Dr. Andrew Stanfield, Co-director of the Patrick Wild Centre for Research into Autism, Fragile X Syndrome and Intellectual Disabilities, said: "'These findings are particularly important as metformin is a commonly used drug for other conditions so we already know a lot about its safety profile....
Additional studies are needed to clarify the importance of premutation screening in patients with movement disorders or other associated atypical features at onset, such as paraparesis. 展开 关键词: Fragile X Mental Retardation Protein Fragile X Syndrome 脆性X染色体综合征 ...
(based on weight) improved symptoms in children with the inattentive ADHD subtype.91In a separate randomized double-blind trial, ALC had a beneficial effect on hyperactivity and social behavior in 51 young boys with fragile X syndrome and ADHD.89However, a 2011 study of boys and girls with ...