Overdiagnosis definition should include symptomatic and asymptomatic patientsdoi:10.1136/bmj.h869BMJ
Stroke recurrences in patients with symptomatic vs asymptomatic middle cerebral artery disease. Neurology. 2005;65(6):859-864. doi:10.1212/01.wnl.0000175983.76110.59 PubMedGoogle ScholarCrossref 5. Flaherty ML, Flemming KD, McClelland R, Jorgensen NW, Brown RD Jr....
The natural history of diagnosed gallstone disease in symptomatic and asymptomatic patients. Only two of these deaths were biliary tract related, and both were in the symptomatic group. This study suggests that patients with silent stones do not need to be operated on prior to the development of...
the proportion of patients with at least 1 class improvement in NYHA functional classification was 4-fold greater with mavacamten compared with placebo (59.3% vs 14.8%); an overall improvement from more severe HF symptoms (class II or III) to becoming less symptomatic or asymptomatic (class ...
(A) 50–99% symptomatic, asymptomatic, and no intracranial stenosis. (B) Proximal extracranial internal carotid artery stenosis, extracranial vertebral artery stenosis, 50–99% intracranial stenosis, and any stenosis (extracranial or intracranial). The independent baseline predictors of any 50–99% int...
Unique features of DMT development include possible extension to asymptomatic preclinical populations; use of biomarkers to select patients, show target engagement, and support disease-modification; and expectation of cumulative benefit and increasing drug-placebo difference with continued adherence to the ...
Definition of joint contact area and the anatomical coordinate system The surface-to-surface least-distance distributions between the humerus and radius models and between the humerus and ulna models were calculated by a point-to-surface distance calculation algorithm using custom-written software24. Art...
post-bronchodilator FEV1/FVC < LLN) attending scheduled follow-up consultation with FEV1>50%, age-, and sex-matched to group 1; 3) healthy subjects: asymptomatic subjects, never or former smokers with a smoking history <10 pack-years, with normal spirometry values (FEV1/FVC, FEV1, and FVC...
In a post hoc analysis of the intention-to-treat population using the SCAI definition of periprocedural MI, the difference was also smaller (10 [1.2%] vs 5 [1.3%]) (eTable 7B in Supplement 4). Considering only nonperiprocedural MIs, the difference is further narrowed (8 [0.8%] vs 5 ...
23 It is yet to be determined whether these more aggressive approaches will improve benefit for patients in light of the probable increased toxicity and effect on quality of life as, by definition, patients are asymptomatic. In our study, treatment discontinuation due to intolerability was not ...