It transcriptionally activates XPC, a platinum-DNA damage recognition protein in the global genome repair (GGR), sub-pathway of nucleotide excision repair (NER). The goal of this research is to investigate the effect of a novel combination of cisplatin, sodium arsenite (NaAs02) and hyperthermia ...
Alpha-fetoprotein (Afp) is the most abundant serum protein in the developing embryo. It is secreted by the visceral endoderm, its derivative yolk sac endod... GS Kwon,ST Fraser,GS Eakin,... - 《Developmental Dynamics》 被引量: 150发表: 2010年 ...
Interestingly, 1,8-naphthalimide derivatives 1 and 7 inhibited a human demethylase FTO (the fat mass and obesityassociated protein). Computer simulation studies further indicated that 1 and 7 entered the FTO's structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. ...
JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which ... L Zhao,Y...
Translationally controlled tumor protein is a target of tumor reversion By inhibiting the expression of TCTP, the number of revertant cells was raised to 30%, instead of the reported rate for spontaneous flat revertants of ... M Tuynder,G Fiucci,S Prieur,... - 《Proc Natl Acad Sci U S...