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Adjuvants play the key role in shaping the quality and magnitude of the immune response to protein and inactivated vaccines. We previously developed a protein subunit COVID-19 vaccine, termed ZF2001, based on an aluminium hydroxide-adjuvanted tandem-repeat dimeric receptor-binding domain (RBD) of...
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No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more aboutSyneos Health. Additional Information: Tasks, duties, and responsibilities as listed in this job description are...
Full size image Analysis of circRNA changes in fasudil-treated APPswe/PSEN1dE9 mice CircRNAs play a vital role in neurodegenerative diseases, particularly in AD33. Our results illustrated 34 differentially expressed circRNAs in ADNS versus WT, including 17 up and 17 down (Fig. 4D and Supplementary...
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Intriguingly, we found the concentration of β-AR agonist which we administered in our studies did not have a significant role in mediating an avoidance behaviour to the context in APP/PS1. It was recently demonstrated that β2-AR expressed in astrocytes are the primary mediators of fear based...
Full size image Analysis of circRNA changes in fasudil-treated APPswe/PSEN1dE9 mice CircRNAs play a vital role in neurodegenerative diseases, particularly in AD33. Our results illustrated 34 differentially expressed circRNAs in ADNS versus WT, including 17 up and 17 down (Fig. 4D and Supplementary...
AD-related substitutions in the gene encoding for the Amyloid Protein Precursor (APP) have contributed important insight into the role of Aβ in cognition. APP can be cleaved by β-secretase/BACE1, after which it is cleaved by the γ-secretase complex to yield Aβ. Alternatively APP can be...
Hence, we generated APPSWE/PS1ΔE9 mice lacking the type-1 IFN alpha receptor-1 (IFNAR1, APPSWE/PS1ΔE9 x IFNAR1−/−) aged to 9 months to investigate the role of type-1 IFN signaling in a well-validated model of AD. APPSWE/PS1ΔE9 x IFNAR1−/− mice displayed a ...