Synaptic vesicle 2C and its synaptic-related function 3 Structure and distribution of the SV2C protein The human SV2C protein has two isoforms, SV2C1 and SV2C2, which contain an open reading frame coding for pr
Although the structure and protein interactions of SV2 suggest multiple possible functions, its role in synaptic events remains unknown. To explore the function of SV2 in an in vivo context, we generated mice that do not express the primary SV2 isoform, SV2A, by using targeted...
aThe structure of the LD4A–HCA2 interaction.bThe protein–protein interaction between HCA2 and LD4A. The interacting residues are shown as sticks, and the hydrogen bonds are shown as dashed lines.cCryo-EM map of the binding interface between LD4A and HCA2.dThe protein–glycan interaction be...
approximately 30% of epileptic patients have medically refractory seizures; other limitations in most traditional ASMs include poor tolerability and drug-drug interactions. Therefore, there is an urgent need to develop alternative ASMs
evidence for altered synaptic function comes from in vivo neuroimaging studies which show lower brain volumes28and altered functional connectivity in schizophrenia relative to controls29, which may reflect altered synaptic density and/or function in schizophrenia (although there are other potential explanatio...
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2.3.5 Markup Compatibility Schema 2.4 ShapeSheet Properties 2.5 Formula Expressions and Evaluation 3 Structure Examples 4 Security 5 Appendix A: Full XML Schema 6 Appendix B: Product Behavior 7 Change Tracking 8 Index Ladda ned PDF Läs på engelska ...
2.1.1 Section 2, Document Structure 2.1.2 Section 2.1, Document Roots 2.1.3 Section 2.1.1, Document Root Element Content Models 2.1.4 Section 2.1.2, Document Root Attributes 2.1.5 Section 2.2, Document Metadata 2.1.6 Section 2.2.1, Pre-Defined vs. Custom Metadata 2.1.7 Section 2.3,...
We identified two major conformations of SV2A in mouse brain tissue: first, a compact, funnel-structure with a pore-like opening towards the cytoplasm; second, a more open, V-shaped structure with a cleft-like opening towards the intravesicular space. The large differences between these ...
Background: Autism, a highly heritable psychiatric condition, is hypothesised believed to be associated with altered synaptic structure and function, as indicated by findings from genetic, post-mortem, and pre-clinical studies. Aims & Objectives: In this study, we used pos...