We found that the protein SUZ domain–containing protein 1 (SZRD1) interacts with the key NMD factor up-frameshift 1. When recruited to NMD-sensitive reporter gene transcripts, SZRD1 increased protein production, at least in part, by relieving translational inhibition. The conserved SUZ domain ...
Methods RNA interference technology was used to down-regulate the expression of protein SUZ12 and Cdc25C. The lentiviral transfection method was used to construct Cdc25C over-expression cell lines and its negative control cell lines in Hela,which was screened by complete medium containing puromycin...
SUZ12 interacts with EZH2 and EED through its C-terminal VEFS domain and with JARID2, AEBP2, EPOP, and PCL1–3 through other parts of the protein (Chen et al., 2018; Kasinath et al., 2018; Kloet et al., 2016; Youmans et al., 2018). The effect of JAZF1-SUZ12 on PRC2 ...
yb-4528R CSFV Polyprotein猪瘟病毒抗体 yb-2376R Cytochrome c oxidase subunit 2细胞色素c氧化酶亚型2抗体 yb-3822R Cyclin G2周期素G2抗体 yb-2373R Ceruloplasmin铜蓝蛋白抗体 yb-4608R CUEDC2CUE结构域蛋白2抗体 yb-3890R NDUFS1(75kD)线粒体复合物NDUFS1蛋白抗体 yb-4019R Thromboxane synthase血栓素合...
Polycomb repressive complex 2 (PRC2) catalyzes methylation on lysine 27 of histone H3 (H3K27) and is required for maintaining transcriptional patterns and cellular identity, but the specification and maintenance of genomic PRC2 binding and H3K27 methylat
(A) Domain architecture of the Jarid2- and Aebp2-containing holo-PRC2 complex is outlined. Compositions of the catalytic module and the nucleosome-binding module of the core PRC2 complex are indicated. Protein domains of Suz12, Rbbp4, Jarid2, and Aebp2 included in the crystal structure ...