Glioblastoma (GBM) is the most common malignant CNS neoplasm, the prognosis of which remains poor even after multidisciplinary treatment. The 5-year overall survival rate of GBM is less than 10% and has remained unchanged for more than 50 years. Because GBM patients rarely survive over a ...
The findings confirmed the survival benefit observed at the study’s interim analysis, which led to the October 2015 FDA approval of the Optune combination for use in patients with newly diagnosed GBM following surgery, chemotherapy, and radiation therapy. “[Optune] should be considered the new s...
25 This first and rate limiting step to divert substrates from glycolysis to serine synthesis is catalysed by 3-PG dehydrogenase (PHGDH).26 Focal amplifications of the PHGDH gene have been described in breast cancer and melanoma.18,27 Recently, it has been demonstrated for these two entities ...
Glioblastoma multiforme is the most common primary malignant brain tumour in adults with an incidence rate of 3.7 per 100,000 person-years, though geographical variation exists1. Despite an increasing understanding of the underlying pathophysiology, glioblastoma remains an incurable disease with high morta...
chemotherapy, 5-year survival rates in GBM were 3.6%, Stupp remarked in his presentation. When temozolomide was added to radiation, 5-year survival improved to 9.8%. Now, however, “EF-14 establishes a new landmark 5-year survival rate of 13%, and long-term remission in GBM is now...
GBM is the most common and aggressive clinical manifestation of glioma, with a 5-year survival rate of <3% compared to other primary gliomas, which have a 5-year survival rate of at least 50% [1, 2]. Patients diagnosed with primary GBM (IDH-wildtype) represent approximately 90% of ...
Concomitant TMZ and RT increased the 2 year OS rate from 14 to 41 % and from 5 to 24 % in patients 65–70 and ≥71 years old, respectively. Grade 3–4 thrombocytopenia was significantly more frequent in the present cohort. Survival of elderly patients with GBM may be prolonged with the...
Our scoring measure of interest was the AUC. For each model, we selected parameters that produced the highest AUC in the validation set. Parameters of interest were learning rate, number of estimators, maximum depth of tree, minimum number of samples per node to be considered for splitting, ...
(MACE) as an alternative outcome based on the Meta cohort. Initially, stratifying patients into high and low AIHFLevel groups based on median values, the Kaplan–Meier curves revealed a significantly higher rate of MACE in the high AIHFLevel group (P < 0.0001) (Fig.5a). Significant ...
(DHW30), high-frequency short-duration daily SST variation31, daily rate of temperature increase (DTR32,33), pre-heat stress (thermal history33,34) and the acute presence/absence of heat stress30. Although these metrics are potentially powerful tools to forecast stressful events, ground-truth...