which provided for the development of a clinical staging system: Stage I with none or one factor and a two-year survival rate of 100 percent; Stage II with two or three factors and two-year survival of 72.2 percent; and Stage III with four or five factors and two-year survival of 0 ...
Chronic myeloid leukemia (CML) is a myeloproliferative clonal disorder resulting from a neoplastic transformation of hematopoietic stem cells [1]. CML affects slightly more males than females and mainly between the fifth and sixth decades of life [2]. In Italy, the crude incidence rate is 1.61 ...
The relapse-free survival (RFS) rate was 77% in the cohort of patients who received Orca-T vs 62% in the cohort of patients who received PTCy (HR, 0.5; 95% CI, 0.3-0.9). Furthermore, the non-relapse mortality (NRM) rates with Orca-T and PTCy were 3% and 16%, respectively (HR...
These anthracycline-tolerant persisters were designated ATCs and could be cultured over a long period of time in the presence of 225 ng/mL doxorubicin. Their growth rate was similar to the parental polyclonal cell population (Figure 1B) and the ATCs were resistant to doxorubicin concentrations up...
Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. ...
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require life-long treatment due to leukaemic stem cell (LSC) persistence. LSCs reside in the bone marrow (BM) niche, which they modify to t
The relapse-free survival (RFS) rate was 77% in the cohort of patients who received Orca-T vs 62% in the cohort of patients who received PTCy (HR, 0.5; 95% CI, 0.3-0.9). Furthermore, the non-relapse mortality (NRM) rates with Orca-T and PTCy were 3% and 16%, respectively (HR...
Currently, HHT is the only ribosome inhibitor specifically used for the treatment of acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and myelodysplastic syndrome (MDS)5. HHT induces the rapid turnover of several key oncoproteins, including c-Myc and Mcl-1, and potently triggers ...
Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytarabine (n=158) or using IM after IFN-fai
Such a small number cells owning the characteristics of tumor stem cells were also found in many other hematology malignity diseases, such as chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), and acute lymphocytic leukemia (ALL) [19–22]. Therefore, studying the differences in ...