Novel Updates The future unfolded on a magnificent scale into the Interstellar Age. Humanity finally solved the space warp technology, but when humanity transported themselves into the other end, they discovered that place neither had a past nor future, nor was there any land under the starry ski...
the impossibility of communication with and understanding of alien intelligence, despair about human limitations, and humanity's place in the universe. One of Lem's major recurring themes, beginning from his very first novel, The Man from Mars, was the impossibility of communication between...
There is one-sidedness in explaining the structure and function of SEs from the 2D perspectives of “SE-regulated gene loop”. Recently, phase-separated multi-molecular assemblies with Hi-C-sequencing further provided a general regulatory mechanism underlying SE formation, function, and properties [49...
light novel. While the logo used in Super Smash Bros. is the Japanese logo and prominently features the series title written in kanji, the title is also written out in English alongside it. Sonic Forces logoThe logo used for Sonic Forces-related content is the game's official logo, compl...
et al. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat. Genet. 52, 594–603 (2020). Article CAS PubMed MATH Google Scholar Andersson, A. et al. Spatial deconvolution of HER2-positive breast tumors reveals novel intercellular relationships. bioR...
staining was either weak or undetectable. The strong nuclear miR-1246 staining in CRC tissue is consistent with it originating from cleavage of spliceosomal U2 snRNA30. Many other small RNAs in supermeres are derived from the extended RNU2 family, which includes many gene copies and pseudogenes....
Cytokine induced memory-like natural killer (CIML NK) cells combined with an IL-15 super-agonist (N-803) are a novel modality to treat relapsed/refractory head and neck cancer. We report data from a phase I trial of haploidentical CIML NK cells combined
LINC01977 interacted with SMAD3 to induce its nuclear transport, which facilitated the interaction between SMAD3 and CBP/P300, thereby regulating the downstream target gene ZEB1. Additionally, SMAD3 up-regulated LINC09177 transcription by simultaneously binding the promoter and SE, which was induced ...
A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region. J. Virol. 70, 7695–7705 (1996). Article CAS PubMed PubMed Central Google Scholar Jones, D. et al. Kinetics of dCas9 target search in Escherichia coli...
In addition to NPF-based analyses, we compared the predicted proteins in the novel lineages to a variety of databases and gene phylogenies to understand their metabolism (see “Methods”). The distribution of key metabolic proteins based on presence/absence of protein families (using MEBS: see me...