SUMOylation pathwaySUMOs (small ubiquitin-like modifiers) are ubiquitin-like proteins (Ubls) that become conjugated to …Lee, MingTaDasso, Mary
对SUMOi处理的OCI-Ly1和SU-DHL-4 DLBCL细胞系进行了蛋白质组学分析。结果显示,SUMOi对MHC-I/APM通路成员HLA-A、HLA-B、B2M、TAP1、TAP1和TABP的诱导(图2A),且pathway分析进一步证实了这一点(图2B)。 综上所述,确定了激活的SUMOylation在限制MHC-I/APM通路中的保守作用,并表明抑制SUMOylation恢复了B细胞...
Genome-scale CRISPR–Cas9 screens have identified genetic backgrounds that are vulnerable to inhibition of the SUMO modification pathway in human cells. These findings reveal that protein SUMOylation is essential for cell proliferation owing to a key role in complementary catenane resolution pathways that...
Human proteins of the SUMO pathway (PDF 217 kb) Related links FURTHER INFORMATION Frauke Melchior's homepage Glossary SUMO-interaction/binding motif A short motif in proteins that mediates non-covalent interaction with SUMO. This motif is characterized as hxhh or hhxh (in which h is Val, Ile...
CancerCel l25, 1–14(June 16)2014ª2014 Elsevier Inc 1Cancer Cel lumoylation Required for Basal Breast Cancerlease cite this article in press as:Bogacheket al ,Sumoylation Pathway Is Required to Maintain the Basal Breast CancerSubtype,Cancer Cel l (2014),ttp://dx doi org/101016/j ccr...
Targeting the sumoylation pathway in cancer stem cells Cancer stem cells (CSCs) represent a subset of tumor cells with tumor-initiating potential. We recently demonstrated that inhibition of the sumoylation pat... MV Bogachek,JP De Andrade,RJ Weigel - 《Molecular & Cellular Oncology》 被引量...
The HPV E6 proteins utilize the host ubiquitin-proteosome pathway to target several cellular proteins for degradation. Several HPV proteins are substrates for sumoylation, so the objective of this study was to determine if HPV E6 proteins interacted with or influenced the parallel host sumoylation...
A number of factors, yielding the highest scores, were identified as members of the SUMOylation pathway. We identified Ubc9, the E2 conjugating enzyme as well as Sae1 and Sae2, enzymes responsible for activating E1, as factors involved in restricting AAV. The restriction effect, mediated by ...
Nacerddine, K. et al. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.Dev. Cell9, 769–779 (2005). ArticleCASPubMedGoogle Scholar Blanc, M. et al. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.PLoS...
For SUMOylation of MRE11, it has been reported that MRE11 is SUMOylated by adenoviral protein E4-ORF3 and then degraded by E1B-55K and E4-ORF6 through the ubiquitin proteasome pathway, which facilitates adenoviral infection48. However, another study showed that the protein level of MRE11 ...