therefore I am” [cogito ergo sum] which convinces me that I speak the truth, apart from the fact that I see very clearly that one has to exist in order to think, I judged that I could adopt as a general rule that those things we conceive very clearly and distinctly are all true. ...
“As a rule, smaller breeds mature more quickly than larger or giant breeds,” Dr. Klein says. Since I’m raising a large-breed puppy, this is something that is always on my mind. Even though Sirius is much larger, and nearly twice as old as her best friends (a pair of six-month...
IL-13 itself did not affect the mRNA and protein levels of components of SUMOylation machinery in human bronchial epithelial cells, 16HBE cells (Supplementary Fig. 3a, b). To rule out the possibility that 2-D08 attenuating the goblet cell metaplasia was secondary to its inhibitory effects on...
This is to rule out the possibility that the overexpression of SUN1-sfGFP or the antibodies used for immuno-purification of the nuclei altered the sample composition. Overall, our Western blot data match most of the observed differences in the nuclear proteome. We found a strong increase in ...
We note, however, that we cannot definitively rule out that deletion of these 15 amino acids causes misfolding of the VR that could itself disrupt mitochondrial localisation of Drp1. Figure 2: SUMOylation within the VR of Drp1 regulates binding to Mff. (a) Schematic of Drp1 domains showing...
To rule out the possibility that PCSK9 was involved in LDLR elevation upon SENP1 overexpression, CRL1601 and stable cells were incubated with the purified PCSK9 protein at various concentrations in cholesterol-depleting medium containing lipoprotein-deficient serum, lovastatin and minimal amount of ...
“I think, therefore I am” [cogito ergo sum] which convinces me that I speak the truth, apart from the fact that I see very clearly that one has to exist in order to think, I judged that I could adopt as a general rule that those things we conceive very clearly and distinctly are...
In a recent paper, Xiao [38] concludes that the studies of Bonnet et al. [35] cannot rule out the possibility that Tax sumoylation and/or nuclear bodies may be involved in the transcriptional regulation of some specific NF-κB target genes. This study supports the idea that both Tax-1 ...
Finally, we cannot rule out that a different choice of exposure and experimental protocols may have allowed the observation of subtler effects.Availability of data and materials The raw data for this manuscript are included in Additional file 1.Abbreviations ANOVA: analysis of variance BASO: ...
[35] cannot rule out the possibility that Tax sumoylation and/or nuclear bodies may be involved in the transcriptional regulation of some specific NF-κB target genes. This study supports the idea that both Tax-1 and Tax-2B need to be targeted to specific subcellular domains to achieve NF-...