The sulforhodamine B (SRB) assay was developed by Skehan and colleagues to measure drug-induced cytotoxicity and cell proliferation for large-scale drug-screening applications. Sulforhodamine B, an anionic aminoxanthene dye, can form an electrostatic complex with the basic amino acid residues of protei...
The study performed with the sulforhodamine B (SRB) assay [141]. Cytotoxic data revealed the importance of fluoro-substituent on 4-aniline and 4-methylpiperazin-1-yl in place of morpholino at R1 for anti-proliferative activity while the presence of the methoxyl group at R3 decreases the potency...
Sulforhodamine B (SRB) cell cytotoxicity assay has been widely used for drug toxicity screening and cell proliferation detection against different types of cancerous and non-cancerous cell lines. In addition, this assay does not depend on the metabolic activity of the cells and therefore shows less...
The sulforhodamine B (SRB) assay was developed by Skehan and colleagues to measure drug-induced cytotoxicity and cell proliferation for large-scale drug-sc... W Voigt - 《Methods in Molecular Medicine》 被引量: 241发表: 2005年 Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Res...
[1]. Orellana EA, et al. Sulforhodamine B (SRB) Assay in Cell Culture to Investigate Cell Proliferation. Bio Protoc. 2016 Nov 5;6(21). pii: e1984. 公司简介 武汉科斯坦生物科技有限公司是一家致力于前沿生物技术研发与成果转化的创新型高科技企业。
Various assays are used to evaluate the cytotoxic effect of chemicals on cultured cells. The sulforhodamine B (SRB) colorimetric assay is based on the ability of the SRB dye to bind basic amino acid residues on proteins. In contrast, the MTT (dimethylthi
Colourimetric methods in general, and the sulforhodamine B (SRB) assay in particular [36], appears to be the most convenient alternative to hemacytometer counting. The SRB binds to the basic amino acids of cellular macromolecules. The SRB assay is commonly used for cell determination in monolayer...
The sulforhodamine B (SRB) assay was developed by Skehan and colleagues to measure drug-induced cytotoxicity and cell proliferation for large-scale drug-sc... W Voigt - 《Methods in Molecular Medicine》 被引量: 241发表: 2005年 Comparison of antitumor activity of vitamins K1, K2 and K3 on ...
Sulforhodamine B (Fig. 10.4) is a fluorescent dye with uses spanning from laser-induced fluorescence to the quantification of cellular proteins of cultured cells. The SRB assay is based on binding of the dye to basic amino acids of cellular proteins, and colorimetric evaluation provides an estimat...