The present study examined whether sulforaphane combined with vitamin D at clinically relevant concentrations improved the cytotoxicity of the compounds alone towards DU145 and PC-3 human prostate tumor cells. To assess the anticancer activity of this combination, we analyzed cell viability (MTT assay)...
Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells Nutrients, 15 (12) (2023) Google Scholar [90] M. Wang, et al. Effects of autophagy modulator on autophagy and uridine 5'...
Chagas CE, Purgatto E, Cavalher FP, Camargo AA, Jordão AA Jr, Vannucchi H, Scolastici C, Ong TP, Moreno FS (2012) Chemopreventive effects of the dietary histone deacetylase inhibitor tributyrin alone or in combination with vitamin a during the promotion phase of rat hepatocarcinogenesis. J...
vitamin D was equal to treatment with sulforaphane alone, demonstrating no improvement in outcome when using the combination (Figure 2A). Only 8 µM sulforaphane combined with vitamin D decreased the cell viability of PC-3 cells when compared with the compounds alone, with CI = 0.14 (Figure ...
Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells. Nutrients 2023, 15, 2742. [Google Scholar] [CrossRef] [PubMed] Pei, Y.; Wu, B.; Cao, Q.; Wu, L.; Yang, G. ...
Since in PD the treatment with vitamin E showed conflicting results, the authors evaluated, through the modulation of thioredoxin levels, the antioxidant capacity in mouse embryonic fibroblasts and SH-SY5Y cells. It is noteworthy that Nrf2 modulated the gene expression of thioredoxin; indeed, ...
Cruciferous vegetables are often of interest as nutritious foods since they are a source of bioactive compounds, including glucosinolates, phenolics, flavonoids, and vitamin C [2,3]. Recent reports showed that the high radical scavenging activity of cruciferous vegetables benefits from these bioactive ...
[18]. SFN could activate a series of phase II enzymes and antioxidant enzymes that could react with active oxygen molecules. Compared with small-molecule antioxidants, such as vitamin C or K, phase II enzymes and antioxidant enzymes could persist for a longer time. Thus, the antioxidant effect...
[18]. SFN could activate a series of phase II enzymes and antioxidant enzymes that could react with active oxygen molecules. Compared with small-molecule antioxidants, such as vitamin C or K, phase II enzymes and antioxidant enzymes could persist for a longer time. Thus, the antioxidant effect...