The action of the sulfonamides and related sulfones is bacteriostatic rather than bactericidal. Numerous studies have been made to find a correlation between the physicochemical properties of the sulfonamides and their bacteriostatic activity. Relationships to the degree of ionization, lipid鈥搘ater ...
The action of the sulfa drugs and related sulfones is bacteriostatic rather than bactericidal. Numerous studies have been made to find a correlation between the physicochemical properties of the sulfonamides and their bacteriostatic activity. Degree of ionization, lipid鈥搘ater solubility, electron ...
Even at very high concentrations SA act only bacteriostatically, whereas TMP alone can cause bactericidal effects if a certain threshold of concentration (≥1 μmol/l) is passed. (A decrease in numbers of cells of about 90% can be obtained within 8 h.) Combinations of TMP and SA at ...