Chronic granulomatous disease: mode of action of sulfamethoxazole/trimethoprim. Pediatr Res 1981; 15:1533±7.Gmtinder FK, Seger RA (1981)Chronic granulomatous disease: mode of action of sulfamethoxazole/trimethoprim. Pediatr Res 15:1533-1537
Mode of Action: Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and...
Purpose: biochemical research. Sulfonamide antibiotics inhibit dihydropterate synthetase, thereby blocking the synthesis of dihydrofolate. Mode of action: inhibiting the synthesis of folic acid in prokaryotes Saving: RT
The cultures were washed twice and resuspended in M9-glucose then inoculated into each well of a 96-well flat-bottom plate (Corning) containing M9-glucose containing different concentrations of SMX, TMP, or combination of SMX and TMP. Growth was monitored in a Synergy H1 Hybrid Multi-Mode ...
Chronic granulomatous disease: mode of action of sulfamethoxazole/trimethoprim. Four possible modes of action for the clinically observed effectiveness of sulfamethoxazole/trimethoprim in chronic granulomatous disease were evaluated: (... FK Gmünder,RA Seger - 《Pediatric Research》 被引量: 74发表: 1981...
Agent NameMode of Interaction AcetoheximideConcomitant administration with sulfonamides may enhance the effect of this agent by displacement from protein-binding sites. ChlorpropamideConcomitant administration with sulfonamides may enhance the effect of this agent by displacement from protein-binding sites. ...
buffer(pH3.0)–methanol(from31:69to69:31)asmobilephaseingradientmode. Themobilephaseflow-rateandsamplevolumeinjectedwere1ml/minand20l,respectively.Theselectedwavelength forthedeterminationwas255nm.Thelimitsofquantificationgofrom200g/lforSDMto1100g/lforBROandtherun timewas13min. Themethodwasapplied...
Investigations on the mode of action of the combination sulfamethoxazole-trimethoprim.AngehrnThenChemotherapy
Consequently, Lemna gibba was exposed to SMX to evaluate phytotoxic potency and mode of action (MOA) by HPLC-MS/MS measurement of p-aminobenzoic acid (pABA) metabolite levels, a precursor to folate biosynthesis and substrate of the target enzyme dihydropteroate synthase (DHPS). pABA levels ...
Admittedly, some of the more sophisticated refinements have been planned by chemical methods, and the introduction of the semisynthetic penicillins and cephalosporins was a major advance in antimicrobial therapy. Nevertheless, empiricism was inevitable, and history has shown that the mode of action of ...