Elevated Heart Rate Triggers Action Potential Alternans and Sudden Death.Translational Study of a Homozygous KCNH2 Mutation. Schweigmann U,Biliczki P,Ramirez RJ,et al. PLoS ONE . 2014Schweigmann, U., Biliczki, P., Ramirez, R. J., Marschall, C., Takac, I., Brandes, R. P., et al....
Diabetes affects SCD through heart failure, ventricular arrhythmias, autonomic neuropathy, nocturnal hypoglycemia, and micro/macrovascular changes27,32,33,34. In the current study, the risk of SCD has been elevated more than 2.5-fold by diabetes in the multivariable model which contributes to 20% ...
Apart from those mentioned, other SCD-related risk factors that can be evaluated in clinical laboratories include (i) left ventricle (LV) dysfunction, (ii) history of heart failure (HF), (iii) left ventricular hypertrophy, (iv) poor heart functional status, (v) elevated heart rate and (vi...
Our study population being from the United Kingdom necessitates further validation of result generalizability to other demographics. Conclusions Elevated TyG index and TyG-BMI levels are linked to heightened SCA risk and earlier onset, with these associations particularly pronounced in women....
Conclusions Elevated TyG index and TyG-BMI levels are linked to heightened SCA risk and earlier onset, with these associations particularly pronounced in women.Availability of data and materials Data can be accessed from a public and open repository. This study was conducted using the UK Biobank Re...
We therefore studied the effect of hypoxia and elevated hypoxia signaling on neonatal mice to investigate the role of ambient oxygen levels in neonatal cardiac matura- tion and sensitivity to sudden death (54). We found that maturation of the cardiac conduction system after birth in mice is ...
TOPLINE: A new study shows sudden cardiac deaths among collegiate athletes decreased over a recent 20-year period, but risks are still elevated among males, Black players, and basketball players, suggesting more intensive screening among these groups is needed. ...
this ongoing inflammation is strongly predictive of clinical events including overall mortality and cardiovascular events, kidney disease, and neurologic disease. Persons with HIV infection are now known to have significantly elevated rates of acute myocardial infarction, heart failure, peripheral arterial di...
Alterations to autonomic function, such as a reduction in heart rate variability or disturbed baroreflex sensitivity, can impair the body's capacity to cope with challenging situations of elevated stress, such as seizures. Here, we summarize data on the incidence of and risk factors for SUDEP, ...
In addition, cardiac ankyrin repeat protein (CARP), a transcriptional regulator that is often up-regulated with heart failure, was also elevated, more often in mutant male than female mice. A strong signal was observed in three of 3 males, but only in one of 3 females (Fig. 4i). ...