In enzymology, a Succinyl-Diaminopimelate Desuccinylase is an enzyme that catalyzes a chemical reaction. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell ...
英文名称:Recombinant Shewanella frigidimarina Succinyl-diaminopimelate desuccinylase (dapE)Recombinant Shewanella frigidimarina Succinyl-diaminopimelate desuccinylase (dapE) is available 1 time fro,中文名称:重组雪腐藻琥珀酸二氨基二甲酰脱糖基
Ubiquitously present in most bacteria, the enzyme metallohydrolase N-succinyl diaminopimelate desuccinylase (DapE) is required for the biosynthesis of meso-diaminopimelate (mDAP) and lysine, both essential components of bacterial peptidoglycan. DapE activity has been recognized as critical for bacterial ...
& Weiss, M. S. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of succinyl-diaminopimelate desuccinylase (Rv1202, DapE) from Mycobacterium tuberculosis. Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68, 1089-1093 (2012)....
N-succinyl-diaminopimelate desuccinylaseDapE is an enzyme that belongs to the meso-diaminopimelate/Lysine pathway. It is recognized as an antimicrobial target, hence compounds that inhibit its catalytic activity are required. The principal features considered in the selection of potential inhibitors for ...
In this study, we have targeted succinyl‐diaminopimelate desuccinylase (DapE) from the Wolbachia endosymbiont of Brugia malayi (WBm), which is involved in the production of lysine and meso‐diaminopimelic acid, an essential component for the formation of bacterial cell walls, and pl...