2.3 Other hazards which do not result in classification none View all 6. NMR Spectrum13C NMR : in DMSO-d6 13C NMR : Predict 1H NMR : parameter in DMSO-d6 1H NMR : Predict Predict 1H proton NMR IR : KBr disc IR : nujol mull 7...
2-Methyl-isoindole-1,3-dione (13): Buff crystals, yield 87%, mp 131–133 °C (lit. =-=[14]-=- mp 134 °C and yield 68%); MS (EI) m/z: (%) 161 [M+, 100%]; 132 (50), 117 (74), 104 (82), 76 (81), 66 (44); 1 H-NMR (DMSO-d6): 3.36 (s, 3H, CH3),...
(DMSO), 2-ethoxyethanol, ethylacetate, ethyl ether, ethylene glycol dimethyl ether (glyme), penlane, hexane, heptane, hexadecane, methanol, 2-methoxyethanol, 2-methoxyethyl acetate, methylethylketone (MEK), methylisoamylketone, methylisobutylketone, butylmethylketone, diisobutylketone, N-methyl-2-...
IR (nujol): ν = 3400, 1620, 1640, 1450, 1370 cm −1 ; 1 H-NMR (600 MHz, DMSO-d6):...Houghten, R.A.; Nefzi, A.; Alvarez-Gutierrez, J.M. Solid phase synthesis of 1,3-disubstituted succinimides. Tetrahedron Lett. 2000, 41, 609-612....
2-Methyl-isoindole-1,3-dione (13): Buff crystals, yield 87%, mp 131–133 °C (lit. =-=[14]-=- mp 134 °C and yield 68%); MS (EI) m/z: (%) 161 [M+, 100%]; 132 (50), 117 (74), 104 (82), 76 (81), 66 (44); 1 H-NMR (DMSO-d6): 3.36 (s, 3H, CH3),...
Staurosporine strongly activated caspase 3/7 in K562 cells, while DMSO had no effect (Figure 2). We also observed a significant increase in the activity of caspase 3/7 in the presence of all tested dicarboximides. Particularly, derivatives 2c, 2d, and 2f were potent activators of apoptosis...
The synthesis of compound o) is shown in Scheme 2. Our compound (5) was isolated as a white solid with an Rf value of 0.38 in n-hexane and ethyl acetate (80:20). The isolated yield of the compound was 97%. The 1H and 13C NMR spectra are shown in (Supplementary Materials) Figures...
1H and 13C NMR spectra were recorded with 75, 100, 300, 400, and 500 MHz spectrometer in CDCl3 and DMSO-d6 solutions. Chemical shifts (δ) are expressed in ppm relative to the internal standard TMS and multiplicities of NMR signals are represented as singlet (s), doublet (d), ...