The critical thing to note here is that the first representation requires the state variables themselves (e.g. the depolarization of membranes in all cell compartments, the configuration of every channel, the phosphorylation status of every enzyme, the expression of every gene product and so on)....
Phosphorylation activates some enzymes and inactivates others; by this means one protein kinase can control several enzymes.All enzymes are controlled by their rate of synthesis. Like all proteins, enzymes are synthesized by ribosomes, which translate the genetic information coded in the ...
we identify THEMIS as an uncharacterized substrate for the phosphatase SHP1. Saturated mutagenesis assays and mass spectrometry analysis reveal that phosphorylation of THEMIS at the evolutionally conserved Tyr34 residue is oppositely regulated by SHP1 and the kinase LCK. Similar toTHEMIS−/−mice,TH...
phosphorylation is more marked than would be expected from impaired upstream activity[182]. These data suggest that facets of the insulin-resistant phenotype, including free fatty acid toxicity, also directly impair eNOS activation in insulin resistance, highlighting the complex multilevel impact upon ...
S4). In contrast, when benzbromarone was used the phosphorylation level increased for both the active forms EYA3 WT and EYA3ED, suggesting that the reduced phosphorylation level is a result of EYA3 autodephosphorylation. Therefore, these experiments showed that Src kinase has phosphorylation sites ...
Gibbs C: The cytplasmic phosphorylation potential. Its possible role in the control of myocardial respiration and cardiac contractility. J Mol Cell Cardiol 17: 727–731, 1985 PubMedGoogle Scholar Chance B, Leigh JS, Kent J, McCully K, Nioka S, Clark BJ, Mais JM, Graham T: Multiple contr...
Although the glucoside was not incorporated into cellular constituents or metabolized for energy, about one-half of the accumulated molecules underwent phosphorylation while one-half remained as the free glucoside. Studies on the inhibition of uptake of the glucoside showed that the affinity of the ...
Moreover, atp7b-/- mutated larvae display a suite of differentially expressed genes, enriched in phototransduction mechanisms, the structural makeup of the eye lens, the sensory perception of light, oxidative phosphorylation processes, and ATPase activities. We also show that copper accumulates in ...
Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation. J. Cell Biol. 182, 753–763 (2008). Tzima, E. et al. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 437, 426–431 (2005). ...
The dopamine transporter is a member of the neurotransmitter:sodium symporters (NSSs), which are responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Experimental evidence elucidat