a subnanomolar affinity 一个纳摩尔亲和力
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology. 2013; 218 :496–505.Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, DeAngelis RA, Resuello RR, Lupu F, Barlow PN, Lambris JD. ...
The FN3hPD-L1-01 binder represents a novel, small, high-affinity binder for imaging hPD-L1 expression on tumor cells and would aid in earlier imaging of tumors. Future clinical validation studies of the labeled FN3hPD-L1 binder(s) have the potential to monitor immune checkpoint inhibitors ...
A further 28-fold affinity improvement could be achieved by mutating residues 32 and 50 of the light chain. The resulting antibody, L19, bound to the ED-B domain of fibronectin with very high affinity (Kd = 54 pm), as determined by real-time interaction analysis with surface plasmon ...
Pini A, Viti F, Santucci A, Carnemolla B, Zardi L, Neri P, Neri DDesign and use of a phage display library Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem 273: 21769-21776 ...
A novel angiotensin analog with subnanomolar affinity for angiotensin converting enzyme,the journal of pharmacology and experi mental. Luke T,Krebs,Jodie M,et al. Therapeutics . 2000Krebs LT, Hanesworth JM, Sardinia MF, Speth RC, Wright JW, et al. (2000) A novel angiotensin analog with ...
Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, Pavlik PA, Martin YC, Donnelly-Roberts DL, Anderson DJ, Sullivan JP, Williams M, Arneric SP, Holladay MW (1996) Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J Med...
Synthesis of three derivatives improved affinity over 20-fold and improved efficacy in cell culture. Crystal structures were consistent with the fragment-based design, enabling further optimization to a K₁ of 50 pM, a 500-fold improvement that required the synthesis of only six derivatives. One...
Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). Eur. J. Med. Chem. 93, 392-400.S.D. Banister, C. Beinat, S.M. Wilkinson, B. Shen, C. Bartoli, S. Selleri, E. Da Pozzo, C. Martini, F.T. Chin, M. Kassiou, Ether analogues of DPA-...
The embodiment of 4-aminoproline residues (Amp) into the arginine-glycine-aspartate (RGD) sequence led to the discovery of a novel class of high-affinity αVβ3/αVβ5 integrin binders [IC50h(αVβ3) 0.03–5.12 nM; IC50h(αVβ5) 0.88–154 nM]. A total of eight cyclopeptides of ...