2. In RA synovium, Bcl6 expressed strongly in the nuclei of synovial lining cells and sublining stroma cells including fibroblast, fibrocytes and endothelial cells (Fig.1). The median of lining Bcl6(+) cells percentage and sublining Bcl6(+) density was significantly higher than that in OA ...
Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes. The IL-1beta-NF-kappaB axis is a key pathway in the pathogenesis of rheumatoid arthritis (RA) and is central in the production of proinflammatory mediators... YR Lee...