Protective effect of recombinant human glucagon-like peptide-1 (rhGLP-1) pretreatment in STZ-induced diabetic mice. J Pept Sci. 2011;17: 499 -504.Wu, Y.L.; Huang, J.; Liu, J.; Jin, M.F.; Gu, M.; Hong, Y.; Wu, Z.R. Protective effect of recombinant human glucagon-like ...
Further, by using the quantitative real-time PCR (qPCR) assay and immunofluorescence staining, EPO was proved to promote the insulin secretion by reducing pancreatic inflammation and apoptosis in diabetic mice. In summary, our results indicate that the mitigation of EPO on pancreatic damage might be...
Effects of Gdf11 gene transfer on STZ-induced type 2 diabetic mice. a Experiment schedule; b the body weight of mice 4 weeks after GDF11 treatment; c non-fasting blood glucose level after gene transfer; d serum glucose level in GTT; e area under the curve of GTT; f blood insulin level...
To prepare the STZ-induced diabetic mouse model, 24 mice, weighing 17-19 g, were fasted for 12 h with free access to water, and then fasting blood glucose levels was determined in blood samples obtained from the tail vein. Mice were then randomly divided into two groups, namely the TIDM...
Mice were fed with a normal diet but, starting from 14 months, half of them were given water with a high sugar (HS) to explore the potential detrimental effects of HS intake to hyperglycemia. Our main outcomes are as follows: i) HS intake alone does not contrib...
Further, by using the quantitative real-time PCR (qPCR) assay and immunofluorescence staining, EPO was proved to promote the insulin secretion by reducing pancreatic inflammation and apoptosis in diabetic mice. In summary, our results indicate that the mitigation of EPO on pancreatic damage might be...
In addition, CD4+CD25− T cells from diabetic mice were more susceptible to CD4+CD25+Foxp3+ iTreg differentiation than those cells from control mice. These data, together with the enhanced frequency of CD4+Helios−Foxp3+ iTregs in the periphery of mice with diabetes, indicate that ...
The diabetic mice were divided into four groups: 1) the diabetic mice group were treatment with saline; 2) the CAPE group were treatment with CAPE at a dose of 20 μmol/kg/day; 3) the low CAPE-pNO2 group were treatment with CAPE-pNO2 at a dose of 20 μmol/kg/day; 4) ...
The test prokinetic drugs metoclopramide (20 mg/kg), domperidone (20 mg/kg) and erythromycin (6 mg/kg) were effective in decreasing small intestinal transit, enhancing gastric emptying and increasing xylose absorption from the GIT in STZ-induced diabetic mice as compared to diabetic control value...
Diabetic cardiomyopathy is a specific type of cardiomyopathy. In DCM, glucose uptake and utilization are impaired due to insulin deficiency or resistance, and the heart relies more heavily on fatty acid oxidation for energy, resulting in myocardial lipid