STXBP5-AS1乳腺癌竞争性内源RNA信号通路乳腺癌是一种多发于女性的恶性肿瘤,是女性中最常见的恶性肿瘤之一,目前由于乳腺癌的病因还未完全清楚,对于乳腺癌的治疗还存在着不尽人意的副作用,因此找到新的治疗乳腺癌策略已迫在眉睫.越来越多的研究表明Lnc RNA在肿瘤的发生与发展中发挥着重要的作用,其有望成为治疗肿瘤...
3细胞葡萄糖消耗量,乳酸产生量,迁移和侵袭细胞数显著降低,凋亡率显著升高,miR-892a表达显著降低(P<0.05).抑制STXBP5-AS1表达可降低紫铆因处理对HSC-3细胞糖酵解,凋亡,迁移及侵袭的影响(P<0.05).结论:紫铆因可抑制HSC-3细胞的迁移侵袭和糖酵解代谢,促进细胞凋亡,其机制可能与调控lncRNA STXBP5-AS1/miR-...
First, our data revealed that the expression levels of STXBP5‐AS1 in 31 NSCLC tissues were lower than in adjacent tissues using quantitative polymerase chain reaction (qPCR) and its expression was significantly associated with tumor metastasis of NSCLC patients. Moreover, CCK‐8, scratch wound ...
Screening the target genes of miR-4425 and Rh2 revealed that Rh2, STXBP5-AS1, and miR-4425 consistently regulated tumor suppressor RNF217 at both the RNA and protein level. Conclusion LncRNA STXBP5-AS1 is upregulated by Rh2 via promoter hypomethylation and acts as a ceRNA, sponging the ...