“dot blot” arrays. This allowed them to profile a small library of molecules in the lysate of Jurkat and Ramos cells for HDAC1, 2, 3, and 6 binding. Bufexamac, an anti-inflammatory drug with unknown target, was identified as preferentially inhibiting HDAC6 in this screen, and its profi...
However, they lack a number of aspects typical for tissues including proper formation of interstitial space and self-organiza- tion into organ-specific architectures such as for exam- ple the formation of cortical layers. Here, organoids have opened entirely new perspectives, especially for analyz-...