Mixing of segments between viruses that infect different organisms can result in pandemics. We have developed a computational pipeline for finding regions within the genetic code where mutation is less often seen; these regions are often important for virus lifecycle. In the ca...
Effect of interferon on thoracic duct lymphocyte output: induction with either poly I:poly C or vaccinia virus. Systemic inoculation of the interferon (IFN) inducer polyinosinic-polycytidylic polyribonucleotide (poly I:poly C) into CBA/J mice produces a significant d... R Korngold,KJ Blank,DM ...
Herpes simplex virus type 1 (HSV-1), the prototypical herpesvirus, has an icosahedral nucleocapsid surrounded by a proteinaceous tegument and a lipoprotein... G Cardone,DC Winkler,BL Trus,... - 《Virology》 被引量: 208发表: 2007年 Identification of Genes Encoding Two Capsid Proteins (VP24 ...
Recent structural studies of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design. The structures of domains of the influenza RNA-dependent RNA polymerase and the ...
Crystal structure of the Rous sarcoma virus intasome. Nature 530, 362–366 (2016). Article ADS CAS PubMed PubMed Central Google Scholar Ballandras-Colas, A. et al. A supramolecular assembly mediates lentiviral DNA integration. Science 355, 93–95 (2017). Article ADS CAS PubMed PubMed ...
VIRUS PARTICLE EXPLORER (VIPER): A REPOSITORY OF VIRUS CAPSID STRUCTURES Virus structures represent mega-molecular nucleoprotein complexes. The three dimensional structures of 74 unique virus capsids, from 21 families and 30 different genera, have been determined at near atomic resolution. We have devi...
The capsid domain of retroviral Gag proteins possesses a single highly conserved subdomain termed the major homology region (MHR). While the mutagenesis of residues in the MHR will impair virus infectivity, the precise solution structure and function of the MHR is not known. To aid the structure...
Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family–oncogenic activation of v-kit involves deletion of extracellular domai... The protein kinase domains of v-kit, the oncogene of the acute transforming feline retrovirus HZ4-FeSV (HZ4-feline sarcoma virus), ...
Therefore, a given virus may be classified based on the type of genome it contains. For instance, the majority of plant viruses have been shown to contain a single strand of RNA (ssRNA). Depending on the type of virus, then, the genome may be single-stranded RNA (ssRNA), single-...
A. Hinnebusch,S. Liebman - 《Cold Spring Harbor Monograph Archive》 被引量: 64发表: 1991年 Structure and Glycosylation Patterns of Surface Proteins from Woodchuck Hepatitis Virus For this reason, substantial efforts to characterize both the similarities and the differences between HBV and WHV are ...