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eFGFs are key regulators of metabolic homeostasis of lipids, glucose, energy, bile acids, and minerals. Alterations in the components of eFGF signaling complex underlie a myriad of metabolic diseases. The recently resolved crystal structures of eFGF signaling complexes open a new door for structure-...
Structural biology follows the sequence-structure-function paradigm, which states that the sequence of a protein determines its structure, which in turn, determines its function1,2,3,4. Experimental structure determination efforts were unable to keep up with the exponential growth of available sequence...
Causality as a New Paradigm in Brain Science Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Volume 4, Issue 6, June 2019, Pages 506-507 Michèle DesjardinsView PDF Abstract Mapping the structural and functional connectivity of the brain is a major focus of systems neuroscience research...
Zhu J, Clark RAF. Fibronectin at select sites binds multiple growth factors (GF) and enhances their activity: expansion of the collaborative ECM-GF paradigm. J Invest Dermatol. 2014;134(4):895–901. ArticleCASPubMedGoogle Scholar Acknowledgments ...
However, as discussed throughout this paper, these paradigm conventions come with substantial deficits in theory- and experiment-backed details revealed with clinical and laboratory techniques including imaging, electrophysiological, histological, bioinformatics, and other methods. These deficits include the ...
From Wolff's law to the Utah paradigm: insights about bone physiology and its clinical applications. Anat. Rec. 262, 398–419 (2001). Article CAS PubMed Google Scholar Eriksen, E. F. Cellular mechanisms of bone remodeling. Rev. Endocr. Metab. Disord. 11, 219–227 (2010). Article Pub...
A gradual paradigm shift has taken place in the past few years through the recognition that galectins also bind glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity. Further, an additional level of functional complexity has ...
In addition, much attention has been focused on DNA gyrase as the intracellular target of a number of antibacterial agents and as a paradigm for other DNA topoisomerases. In this review we summarize the current knowledge concerning DNA gyrase by addressing a wide range of aspects of the study ...
Thus, the H protein serves as a paradigm for the assembly and function of long α-helical supramolecular structures and nanotubes. Highly repetitive in primary and quaternary structure, they are amenable to structure-function analyses using in-frame insertions and deletions as presented herein. ...