Structure-based programming of lymph-node targeting in molecular vaccines . Nature . 2014; 507 ( 7493 ):519–22. doi: 10.1038/nature12978Liu H, et al. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 2014; 507 (7493):519–522. doi: 10.1038/nature12978. ...
A design technique for wire antennas, based on the Structure-Based Evolutionary Programming, is used to design a broadband antenna with an end-fire radiation pattern and a very simple geometry, operating in the 3???16???GHz frequency band, namely, from the S band to the Ku band. The ...
进化算法 进化算法是一类模拟生物进化过程的随机优化算法,主要包括遗传算法(Genetic Algorithm, GA)、进化策略(Evolution Strategy, ES)、遗传规划(Genetic Programming, GP)等。进化算法的基本思想是通过选择、交叉和变异等操作,逐步优化种群中的个体,从而找到问题的最优解。 表2. 最近使用进化算法的从头药物设计方法 ...
25,26. Because of the autocatalytic nature of this process, structure-based methods could be expected to effectively target the catalytic sites on the surface of αS aggregates23. As we show here, the implementation of this idea within an iterative...
Protein tertiary structure prediction is a fundamental problem in computational biology and identifying the most native-like model from a set of predicted models is a key sub-problem. Consensus methods work well when the redundant models in the set are t
Abstract Machine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is especially pressing for neurodegenerative diseases, where the development of disease-modifying drugs has been particularly challenging. To address this problem...
The DGLP framework adopts the logic programming paradigm in order to represent objects whose parts are interconnected in arbitrary ways. Unlike description logics, the decidability guarantees of logic programs do not rely on the tree-model property and, so, the modeller is no longer restricted to...
(3) Additionally, more powerful hardware facilities and programming expertise are needed to boost the viability and effectiveness of DL approaches because to the continuous increase in the complexity of network architecture and data. (4) It is insufficient for the implementation of practical cases due...
Quanbo Ge: propose the key idea and the main solution, and revise the manuscript; Zhongliang Wei:suggestion on the manuscript organization and English writing, and answer to reviewing comments; Tianfa Cheng: discussion on the problem and solution, mainly writing the manuscript, and programming on ...
The advantage of the model include it can (1) effectively integrate the two objectives of economic benefit maximization and pollution minimization by the fractional programming; (2) effectively process the uncertainty by the corresponding uncertainty programming; (3) reflect the impact of uncertainty on...