The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct domains; consisting of tubules, sheets and the nuclear envelope. Several prote...
Endoplasmic reticulum (ER) contacts with mitochondria were recognized several decades ago; major roles in ion and lipid transfer, signaling, and membrane dynamics have been established, while others continue to emerge. The functional diversity of ER–mitochondrial (ER-mito) contacts is mirrored in ...
1) or the trans oligonucleotide (more similar to the dnaX hairpin structure; Fig. 1d, Supplementary Fig. 1). The base of the helix has similarly high probability as the dnaX wild-type hairpin stem-loop. When compared to the stem-loops, the bimolecular helices lack the loops. Based on ...
Endoplasmic reticulum (SER) lacks polysomes it is active in the synthesis of fats and steroids (类固醇) and in the oxidation of toxic substances in the cell • Serve as compartments within the cell where specific products can be isolated and subsequently shunted to particular areas...
We have used a sucrose gradient analysis of pulse-labeled MOPC-315 cells to study the biosynthetic sorting of ERp61, ERp59 and ERp49 and have found no evidence to suggest that these proteins ever leave the endoplasmic reticulum. In addition, all three ERps appeared to have luminally exposed ...
Endoplasmic reticulum (ER) is typically associated with protein biogenesis. However, recent studies suggest that it additionally synchronizes and regulates a plethora of intracellular events owing to its ability to form tight membrane associations, so-ca
additionally matched proteins were the Endoplasmic reticulum membrane-associated oxidoreductin (ERO1), Mitochondrial import inner membrane translocase subunit TIM50, High-mobility group protein, and Ribosomal protein eS10 (Fig.4a, and4b). An additional protein (RING-type E3 ubiquitin transferase) that...
endoplasmic reticulum Endoplasmic reticulum, a continuous membrane system in eukaryotic cells that plays an important role in the biosynthesis, processing, and transport of proteins and lipids. (more) rough endoplasmic reticulum biology Ask the Chatbot a Question More Actions Also known as: RER, ...
In lipid bilayers that mimic the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) membrane, ETM forms a five-helix bundle surrounding a narrow pore. The protein deviates from the ideal α-helical geometry due to three phenylalanine residues, which stack within each helix and between ...
Recent studies have identified a group of kinases collectively referred to as the “secretory pathway kinases,” which are specifically localized to the lumen of the endoplasmic reticulum (ER), Golgi apparatus, and extracellular space3,4,5. Some of these kinases phosphorylate Ser, Thr, or Tyr re...