APP has been implicated as a regulator of synaptic formation and repair[7], anterograde neuronal transport[8] and iron export[9]. It is produced as several different isoforms, ranging in size from 695 to 770 amino acids. The most abundant form in the brain (APP695) is produced mainly by...
1). These data suggest that a majority of the L-isoAsp sites are occluded from the normal repair pathway once in this aggregate form. To determine the ability of these modified forms to accelerate the aggregation of native peptide, seeding of 3.2 mM Aβ20–34 was performed using 10...
Hoshina, M., Boothby, M., and Boime, I.: Cytological localization of chorionic gonadotropin and placental lactogen mRNAs during development of the human placenta. J. Cell Biol. 93: 190–198, 1982. ArticlePubMedCASGoogle Scholar Hoshina, M., Hussa, R., Patillo, R., and Boime, I.: C...
PURPOSE: A method and a device for a marine structure are provided to easily repair, reinforce, and construct a lower side of the marine structure and to prevent a worker from being damaged by an accident.CONSTITUTION: A device of repairing, reinforcing, and constructing comprises a main body...
aUse the boards to repair the ladder near the street lamp in the city square 使用委员会在街灯附近修理梯子在城市广场[translate] aEvil with evil, good will be rewarded. 以罪恶,信誉奖励罪恶。[translate] aWild salmon oil 狂放的鲑鱼油[translate] ...
Chromatin structure, and in particular highly-condensed chromatin, is generally inhibitory to transcription, replication andDNA repair. Therefore, all eukaryotesfaceanother challenge, namely, to counteract the inhibitory effects of chromatin in order to accomplish these essentialcellular processes[1,2]. An...
[61]. Further, it is speculated that longitudinal aponeurotic injuries are more likely to reinjure than transverse injuries due to the fact there is less fibrous repair [61]. In contrast, other work has found injuries with transverse and/or mixed aponeurotic disruption that leads to a scar ...
The potential harmful effects of this lesion are avoided by base excision repair. In Escherichia coli, formamidopyrimidine-DNA glycosylase (Fpg, EC 3.2.2.23) removes 8-oxoG, Me-FaPy, and several structurally related lesions from damaged DNA (7, 8). Fpg is a component of the “GO system”...
Article 11 December 2024 A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size Article Open access 13 March 2020 Cryo-EM structures of the membrane repair protein dysferlin Article Open access 07 November 2024 Data...
Much of our current understanding of microbiology derives from laboratory-based studies of pure cultures, largely motivated by societal needs of improved understanding of the complex physiology of bacteria as relates to pathogenicity, food spoilage, and