1956. Structure of vitamin B12. . Nature 17∶64 - 66.Hodgkin, D. C., Pickworth, J. & Robertson, J. (1955). Structure of vitamin B 12 . Nature, Lond , 176 , 325–8.Brink, C, Hodgkin, DC, Lindsey, J, Pickworth, J, Robertson, JH, White, JG (1954) Structure of vitamin ...
The ATP-binding cassette (ABC) transporter BtuCD mediates the uptake of vitamin B12across the inner membrane ofEscherichia coli. Previous structures have shown the conformations of apo states, but the transport mechanism has remained unclear. Here we report the 3.5 Å crystal structure of the ...
Vitamin B12 (cobalamin [Cbl]) is a cofactor in two essential enzymatic processes in the human body: (i) methionine synthesis and (ii) the conversion of methylmalonic acid to succinyl-CoA, which appears during the catabolism of branched-chain amino acids and odd-chain fatty acids (1, 2). ...
The structure of the monomeric oxygen adduct of vitamin B12r: A single crystal ESR studyFrom ESR single crystal spectra of B 12rO 2 substituted in B 12b the structure of the Co O O fragment was determined at 190°C. The g and A Co tensors were found to be non-coaxial with the ...
Hodgkin’s work was focused around her refinement of the technique of X-ray crystallography, which enabled her to uncover the structure of different biomolecules. This included confirming the structure of penicillin, and discovering the structure of vitamin B12 and later insulin – discoveries which ...
We present a theoretical study of the geometric structure of Co(corrin)(L)(R)+ (R = CH3, i-C3H7 and adenosyl and L = NH3, pyridine and 5,6-dimethylbenzimidazole) as model systems for the vitamin B12 coenzyme. We have optimized the geometries of nine corrin derivatives with axial ligan...
p>The influence of peripheral groups present at the macrocycle ( c- , d- , meso- positions) of vitamin B12 derivatives on catalytic activity in the CH activation of olefins is described. These catalysts are shown to halo the engraved bell. To justify the obtained yields, DFT calculations ...
(PWY 1269,qvalue = 0.07, Fig.4and Additional file2, Table S5). In contrast, several microbial functions were enriched in individuals with asymptomatic diverticulosis, including metabolic pathways involved in the biosynthesis of vitamin B12 (COBALSYN PWY,qvalue = 0.03), glycolysis-related...
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How a protein binds B12: A 3.0 angstrom x-ray structure of B12-binding domains of methionine...Investigates protein-vitamin B12 binding. Crystal structure of a methylcobalamin-containing fragment of methionine synthase from Escherichia coli; Reactivity of cobalamin; Conformational change of ...