Because of its importance in decoding, its small size (～25 000 Da or 73-93 nucleotides) and its availability, tRNA became a favoured example of a nucleic acid molecule in the 1960s for both sequence determination and 3D-structural elucidation. The first primary structural determination of a ...
Which of the following structure would appear in a tRNA molecule:() A. Codon loop B. 5 'end with -C-C-AOH structure C. Anti-codon loop D. D loop E. 3 'end with -C-C-AOH structure 相关知识点: 试题来源: 解析 CDE 反馈 收藏 ...
A transfer of flexibility to the corner of the tRNA molecule disrupts the G19-C56 tertiary interactions. Chemical mapping of the N3 position of cytosine 56 and analysis of self-splitting patterns of tRNAAsp substantiate such a correlation. 展开 ...
YEAST tRNAis one of the more thoroughly investigated tRNA species because it can exist in two conformations which can be interconverted. The native (N) conformer has full biochemical activity, whereas the denatured (D) conformer is inactive with respect to aminoacylation. Although other tRNAs can...
跟DNA比起来,RNA分子是比较短的片段,一般从几倍到上千个核苷酸长。它是单链结构,骨架中的五碳糖是核糖,碱基则是GACU,U替代了DNA中的T。RNA的种类有三种,mRNA(messenger RNA)存在于细胞核和细胞质中,tRNA(transfer RNA)和rRNA(ribosomalRNA)存在于细胞质中。RNA可以通过核孔,DNA则不行。
Transfer RNA (tRNA) is produced as a precursor molecule that needs to be processed at its 3' and 5' ends. Ribonuclease P is the sole endonuclease responsible for processing the 5' end of tRNA by cleaving the precursor and leading to tRNA maturation. It was one of the first catalytic RNA...
The process of RNA editing can occur in various types of RNA molecules, including pre-mRNA, mature mRNA, miRNA, lncRNA, tRNA, and even viral RNA [11,12,13]. An important impact of RNA editing is its ability to challenge the central dogma of biology. When RNA editing takes place in th...
weak structural modifications and stabilization may be readily destroyed. As an example, in an initiator transfer RNA (tRNA) molecule that lacks a methyl group (tRNAiMet), modification at position 58 of the tRNA chain renders the molecule unstable and hence nonfunctional; the nonfunctional chain ...
The functional 5S RNA molecule is at all times an integral part of the 50S ribosomal subunit, whereas tRNA is a transient inhabitant of the ribosome milieu. Thus, it is possible that functional conformations of the 5S RNA molecule need only exist in the context of the ribosome and ...
Nucleotide analog interference mapping (NAIM) can be used to simultaneously, yet individually, identify structurally or catalytically important functional groups within an RNA molecule. Phosphorothioate-tagged nucleotides and nucleotide analogs are randomly incorporated into an RNA of interest by in vitro tra...