Current Opinion in Cell BiologyWilson KL, Weis K (2015) Editorial overview: cell nucleus: nuclear structure and organization-open frontiers in cell and genome biology. Curr Opin Cell Biol 34:v–vi. : 10.1016/j.ceb.2015.07.001
The uptake of these molecules to the nucleus and a displacement by the G4 ligand pyridostatin have been monitored in living cells via fluorescence microscopy 49, 50. G4 specificity was further corroborated by colocalisation with the G4 structure-specific antibody BG4 in fixed cells [50]. The ...
11. The first nuclear localization signal, which localizes yeast ribosomal protein L3 to the nucleus, was reported in 1985.12Although the existence of nuclear import receptors was suspected at the time, first import receptor
nucleus. Similarly as in prokaryotes, for all higher organisms two ribosome subunits are preformed in the nucleolus, which are evolutionary conserved: the small 40S subunit (SSU) containing 18S rRNA, and the large 60S subunit containing 25/28S plus 5.8S and 5S rRNA. After export of the riboso...
(2020), imaging of HIV-1 infection reveals that viral cores remain largely intact until uncoating in the nucleus near sites of integration. CAS PubMed PubMed Central Google Scholar Lee, M. S. & Craigie, R. A previously unidentified host protein protects retroviral DNA from autointegration. ...
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing. RNA editing is a u
Structure of Mitochondria The elaborated structure of mitochondria is vital to the functioning of the organelle. It is generally an oblong organelle, with size that range from one to ten micrometers in length and occur in numbers that correlate directly with the level of metabolic activity of the...
It has previously been proposed that DNA sequences nearer the centre of the nucleus may be protected from DNA damage by those on the periphery (the "bodyguard hypothesis"). Likewise, the chromosomes most enriched with open chromatin are generally situated towards the centre of a nucleus [2]. ...
The presence of a pseudo-repeat in the sequence allows a single PFD to adopt two turns of the β-solenoid, forming the nucleus of the amyloid fold. As well, it gives rise to alternating charges along the fibril axis that support the correct in-register alignment of the β sheets (Figure...
1.6B).46 Hairpin-shaped primary miRNA transcripts (pri-miRNA) are processed to precursor miRNA (pre-miRNA, ≈ 70 nucleotides/nt) in the nucleus by the RNA hydrolase (RNAse) Drosha.47 Pre-miRNA are cleaved to mature miRNas (double-stranded, 2 nt-extended active sequences, ≈ 21–25 nt)...