Before we can understand the manner in which cartilage becomes disrupted or begin to interpret mechanical data derived from the study of whole or part joints, it is essential to know the normal structural arrangement of the tissue. It may then be possible to determine the role of cartilage ...
The neurotransmitter dopamine has central roles in mood, appetite, arousal and movement1. Despite its importance in brain physiology and function, and as a target for illicit and therapeutic drugs, the human dopamine transporter (hDAT) and mechanisms by which it is inhibited by small molecules and...
Several cellular contexts have been proposed for TIPRL, such as regulation of mTOR signaling, inhibition of apoptosis and biogenesis and recycling of PP2A, however, the underlying molecular mechanism is still poorly understood. We have solved the crystal structure of human TIPRL at 2.15 resolution....
Cross-sectional geometric properties of the human femur and tibia are compared in males and females in a number of recent and archaeological population samples extending back to the Middle Paleolithic. There is a consistent decline in sexual dimorphism from hunting-gathering to agricultural to industria...
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core Calina Glynn Michael R. Sawaya Jose A. Rodriguez Nature Structural & Molecular Biology(2020) Cryo-EM structure of an amyloid fibril formed by full-length human prion protein ...
In general, the structural features of bone are important considerations for understanding the difference between bone and humanmade materials. Moreover, the structures designed by nature may greatly inspire innovation in the biomimetic materials area. 11.2.2 Bone chemical composition Apart from the ...
In focus: Streetlamps, cranes and the internal architecture of the human femur We are back after a break! And we have a nice series of posts planned already from numerous guest writers! To kick things off, let’s get hip to bone structure. This week’s post is from Diogo M. Geraldes...
Evolutionary demographic models suggest that the long human post-reproductive lifespan can be understood on the basis of older individuals' contributions to fitness through transfers. Thus far, however, detailed studies examining the motivations for and magnitude of these transfers in traditional subsistenc...
Newly developed fuzzy logic-derived structural parameters were used to characterize trabecular bone architecture in high-resolution magnetic resonance imaging (HR-MRI) of human cadaver calcaneus specimens. These parameters were compared to standard histomorphological structural measures and analyzed concerning ...
cerevisiaeα-glucosidase (maltase) has not been reported, however, the crystal structure of the human lysosomal acid-alpha-glucosidase complexed with acarbose (PDB code: 5NN8) is known. This crystal structure is now commonly used for docking compounds into the active site of α-glucosidase in ...