HerA-driven translocation would propel the DNA towards the narrow annulus of NurA, leading to duplex melting and nucleolytic digestion. This system differs substantially from the bacterial end-resection paradigms. Our findings suggest a novel mode of DNA-end processing by this integrated archaeal ...
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We report the structure of sinuses in the primo vessels on the surfaces of endocardia of atriums and ventricles in the bovine heart. About 1–5 sinuses (0.5–7 μm in diameter) were observed in the crossdoi:10.1007/978-1-4614-0601-3_8Byung-Cheon Lee...
Target- ing the β-adrenergic receptor system through G-Protein- coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart ... G Rengo,P Perrone-Filardi,GD Femminella,... - 《Circ Heart Fail》 被引量: 119发表: 2012年 No association of G-protein-coupled rec...
Our current ability to characterize the human genome is unprecedented [1–3], and is contributing to improve our understanding of the genetic etiology of common diseases. Genetic admixture is one of the caveats for genetic association studies [4], and has fostered the comparative study of the ...
TAO2 is a mitogen-activated protein kinase kinase kinase (MAP3K) that doubly phosphorylates and activates the MAP kinase kinases (MAP2Ks) MEK3 and MEK6. The structure of the kinase domain of TAO2 (1-320) has been solved in its phosphorylated active conformation. The structure, together with...
The lower mantle is found between670kmand2,890kmbelow the surface, and is made from solid rock. The rock is hot enough to melt, but is solid because of the pressure pushing down on it. Upper Mantle Temperature: 1,400°C – 3,000°C ...
Whole- genome sequencing studies have found that some MyRF mutants are associated with birth defects and abnormal development of the heart, genitourinary tract, diaphragm, lung, and eye [15-18]. Some of these disease-related mutants are located on the ICA domain....
This review highlights recent structural breakthroughs of the human PRC2 complex bound to the H3K27 peptide and a small molecule inhibitor, which provide critically needed insight into PRC2-targeted drug discovery. Keywords: PRC2; histone methyltransferase; H3K27me3; nucleosome; structure; drug ...
OBJECTIVE: To describe the types of eating problems experienced by women in an Australian twin population. METHOD: Questions assessing preoccupation with weight or shape, use of various methods of weight control, difficulties with weight control, disordered eating, or binging, were administered to a...