Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control of insulin release from the pancreas. GLP-1 peptide agonists are efficacious drugs for the treatment of diabetes. To gain insight into the molecular mechanism of action of GLP-1 peptides, here we report the crysta...
Bacterial σI factors of the σ70-family are widespread in Bacilli and Clostridia and are involved in the heat shock response, iron metabolism, virulence, and carbohydrate sensing. A multiplicity of σI paralogues in some cellulolytic bacteria have been
ADPglucose pyrophosphorylase has been extensively purified from potato (Solanum tuberosum L.) tuber tissue to study its structure. By employing a modified ... TW Okita,PA Nakata,JM Anderson,... - 《Plant Physiology》 被引量: 0发表: 1990年 The Subunit Structure of Potato Tuber ADPglucose Pyrop...
Net number of water moleculaes removed就是被移动的水分子百分数,移动得越少说明该糖与水越像(这点用直觉来理解就好) Results suggest that sugars 'fit' into hexagonal ice in the following order: Galactose>Glucose>Mannose>Talose Figure 10 3.Other research: MD simulation 目的:在2中我们得到了关于那四...
Recently, a crystal structure of the glucose superfamily EIIC from Bacillus cereus, bcChbC, was crystallized in an inward-facing occluded conformation (Cao et al., 2011). The bound substrate, diacetylchitobiose (GlcNAc)2, was located near the cytoplasmic surface of the protein but was shielded...
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal structures hav
The specific polysaccharide was released from Shigella dysenteriae type 5 lipopolysaccharide by mild acidic hydrolysis and then purified by gel chromatography on Sephadex G-50. The polysaccharide was built up of residues of d-mannose, 2-acetamido-2-deoxy-d-glucose, 3-O-(d-1-carboxyethyl)-l-rhamn...
Its purification, physical and chemical properties and structure were studied by means of some chemical reactions assay and instrumental analysis. The results show that BOS-2 is composed of D-fructose and D-glucose in a molar ratio of about 12:1, which is confirmed by the composition of 12 ...
ZnCl2 was added at this step (final concentration of 0.1 mm). Isotopically 15N/13C-labeled THAP domain (Met1-Lys90) and 15N-labeled THAP domain (Met1-Phe81)) were expressed in minimal (M9) medium containing 15NH4Cl and 15N Celtone and either [13C]glucose or [12C]glucose. Proteins ...
To evaluate the substrate binding of AglΔDCD-UCD, we performed docking simulation using a nigerose molecule, a disaccharide molecule with two glucose molecules linked via a α-1,3 linkage as the ligand. One of the solutions showed positioning at the substrate-binding cleft near D1067, D1090 ...