The trimeric spike (S) protein of the virus decorates the viral surface and is an important target for development of diagnostics, therapeutics and vaccines. Rapid progress in the structural biology of SARS-CoV-2 S protein has been made since the early stage of the pandemic, advancing our ...
The omicron variant of SARS-CoV-2 has been spreading rapidly across the globe. The virus-surface spike protein plays a critical role in the cell entry and immune evasion of SARS-CoV-2. Here we determined the 3.0 Å cryo-EM structure of the omicron spike protein ectodomain. In contrast...
SARS-CoV-2 spike protein treated with cathepsin L 4 FeiLab 3 0 Unusual Homodimer of a Heme‐Copper Terminal Oxidase FeiLab 1 0 Overall architecture of mouse sperm DMT in 48 nm repeats. FeiLab 11 0 Whole cryo-CLEM workflow based on the ELI-TriScope system. FeiLab 6 0 Design and...
SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China, starting from December 2019 that quickly spread nationwide and to other countries around the world1,2,3. Here, to better understand the initial step of infection at an atomic level, we determined the crystal structure of ...
In this review, we provide an overview of the SARS-CoV-2 genome and its coded proteins. We then describe the structures of SARS-CoV-2 proteins and mainly focus on RNA-dependent RNA polymerase and S protein. We provide insights into in situ structures of SARS-CoV-2 that have been solved...
Structure-based antiviral developments in the past two years have been dominated by the structure determination and inhibition of SARS-CoV-2 proteins and new lead molecules for picornaviruses. The SARS-CoV-2 spike protein has been targeted successfully with antibodies, nanobodies, and receptor protein...
Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike ProteinCOVID-19SARS-CoV-2 spike proteinVirtual screeningMolecular dockingPeptidomimeticThe current studies could pave the way for further investigations of these novel and potent compounds against the SARS-CoV-2....
A 3.2 -resolution cryo-EM structure of HexaPro confirmed that it retains the prefusion spike conformation. High-yield production of a stabilized prefusion spike protein will accelerate the development of vaccines and serological diagnostics for SARS-CoV-2. 展开 ...
in the lab, Cheng said. The technology uses a small bit of the SARS-CoV-2 spike protein, called the receptor binding domain. This is the so-called "key" that when bound to receptors on our cells—the lock—starts a molecular cascade of events that allows the virus to infect the cell...
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin. 2020;41:1141–9. Article PubMed PubMed Central Google Scholar Fu YZ, Wang SY, Zheng ZQ, Yi H, Li WW, Xu ZS, et al. SARS-CoV-2 membrane ...