In this lesson, learn what a phosphate group is, what a phosphate group looks like, and the phosphate group formula. Understand some phosphate...
7.1.1 Describe the structure of DNA, including the antiparallel strands, 3' -5' linkages and hydrogen bonding between purines and pyrimidines.DNA is made up of two strands. At one end of each strand there is a phosphate group attached to the carbon atom number 5 of the deoxyribose (this...
The linear distance from the phosphate group of U38 to the phosphate group of G44 is about 21 Å. d, Detailed interactions between G44-U45 and TERT RBD. Intermolecular hydrogen bonds are shown as dashed yellow lines. e, Schematic of TER TBE-TBEL-template conformation when the template...
Self-association and polymerization of the purine nucleotides through lanthanide-mediated bridging of the phosphate groups was suggested previously2,3,20. Indeed, infrared (IR) spectra obtained at high dGMP concentration (100 mM of dGMP) demonstrated large changes in the phosphate region (1150–...
The major determinant of small RNAs that functions as specific triggers of gene silencing is the A-form helical geometry of RNA. The A-form helix and high-resolution structural studies provide a context for discussing the importance of phosphate groups at the 5′ end of the guide strand. Smal...
Binding of cGMP to the active site occurs through direct coordination bonds between two oxygen atoms of the cyclic phosphate group of cGMP on one side and the Zn2+ and Mg2+ ions present in the M-subsite on the other side. The Zn2+ is also critical for catalysis as it acts as a Lewis...
NDPK is involved in the maintenance of the cellular NTP pool, transferring the phosphate group through the histidine phosphointermedier. Interestingly, it seems that this biochemical feature of NDPK is not responsible for its antimetastatic activity [10]. Subsequently, several other biochemical functions...
The orientation of an adjacent arginine residue (R69) suggests that it may also be involved in coordinating the phosphate group. Comparison of the structure with that of E. coli IIAmtl complexed with HPr [PDB: 1J6T] indicates that NM-IIANtr binds in a similar way to the HPr-like enzyme...
and the absence of the symmetricν4vibration at 712 cm−149. The symmetric PO2−stretching peak of ds-DNA backbone at 1083 cm−1was more intense in the 2 h sample comparing with the ds-DNA powder, reflecting an interaction between the phosphate group of ds-DNA and ACC50. Sig...
Structure of the ADP-BeF3-bound ATPase at near-atomic resolution shows network of interactions between the ATPase and ADP-BeF3, which results in a close conformation with the ATPase lobe1 and lobe2 grasping nucleosomal DNA (Fig.2, Supplementary Fig.6). As the mimeticγ-phosphate of ATP, Be...