Structures of prokaryotic NOX5 and eukaryotic DUOX1 have recently shed light on the architecture of the catalytic subunit and the electron transfer pathway32,33,34, but a detailed view of the prototypical NOX2 subfamily is lacking. Compared to NOX5 or DUOX1, NOX2 contains longer extracellular ...
The structure reveals that the p67–Rac1 complex clamps onto the dehydrogenase domain of NOX2 and induces its contraction, which stabilizes the binding of NADPH and results in a reduction of the distance between the NADPH-binding domain and the flavin adenine dinucleotide (FAD)-binding domain. ...
The field of Membrane Protein Structural Biology has grown significantly since its first landmark in 1985 with the first three-dimensional atomic resolution structure of a membrane protein. Nearly twenty-six years later, the crystal structure of the beta2 adrenergic receptor in complex with G protein...
Typically, you use structure types to design small data-centric types that provide little or no behavior. For example, .NET uses structure types to represent a number (both integer and real), a Boolean value, a Unicode character, a time instance. If you're focused on the behavior of a ...
If no connection-specific suffixes are configured or queries for these resultant connection-specific FQDNs fail, then the client can then begin to retry queries based on systematic reduction of the primary suffix (also known as devolution).
We are interested in the problem of predicting secondary structure for small sets of homologous RNAs, by incorporating limited comparative sequence information into an RNA folding model. The Sankoff algorithm for simultaneous RNA folding and alignment is
PknF is one of the 11 Mtb STPKs that has, among other substrates, two FHA domains (FHA-1 and FHA-2) of the ATP-Binding Cassette (ABC) transporter Rv1747. Phosphorylation in T152 and T210 located in a non-structured linker that connects Rv1747 FHA domains is considerate to be the ...
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The allotropy of solid molecular nitrogen is the consequence of a complex interplay between fundamental intermolecular as well as intramolecular interactions. Understanding the underlying physical mechanisms hinges on knowledge of the crystal structures
2). No electron density is visible for the first 18 amino acids of NS3 protease, indicating that after cleavage the N-terminal region of NS3 protease falls off from its own S′ pocket. Overall, the structure of eZiPro captures the post cleavage state of NS2B-NS3 protease. Figure 1: ...