Department of PhysicsMengwen JiaDepartment of PhysicsXiaoqin LiDepartment of PhysicsBiopolymersLuo, L, M Jia, X Li. 2004. Protein structure preference, tRNA copy number, and mRNA stem/loop content. Biopolymers 74:432-447.Luo LF,Jia MW,Li XQ.Protein structure preference,tRNA copy number and ...
Structure of a group II intron in complex with its reverse transcriptase. Nat. Struct. Mol. Biol. 23, 549–557 (2016). Article CAS PubMed PubMed Central Google Scholar Li, S. et al. Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat. Struct. Mol....
Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/...
select article A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes Research articleOpen access A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadrup...
Gallie DR, Feder JN, Schimke RT, Walbot V: Functional analysis of the tobacco mosaic virus tRNA-like structure in cytoplasmic gene regulation. Nucl Acids Res 19: 5031–5036 (1991). PubMedCASGoogle Scholar Garcia A, Cuin JV, Pleij CWA: Differential response to frame shift signals in eukary...
of protein from mRNA is a complex multi-step process that occurs at a non-uniform rate. Vari-ability in ribosome speed along an mRNA enablesref i nement of the proteome and plays a critical rolein protein biogenesis. Detailed single protein studieshave found both tRNA abundance and mRNA sec...
Compare the tRNA and mRNA in terms of their functions and how they are synthesized within the cell. Give three separate analogies for the following: DNA replication, RNA transcription, and protein synthesis. How is the structure of DNA different from the structure of RNA? Draw the specific stru...
these advances allow the prediction of RNA secondary structures for sequences with m6A. We demonstrate, for calculations with human mRNA sequences known to contain m6A, that N6-methylation alters the folding landscape so that m6A is less likely to be buried in a helix, i.e., stacked between...
(42.6% of all bases) They are involved in: helix-loop interactions helix-helix packing helix junctions Play essential role in - 5S – 23S rRNA interaction -CCA interaction of tRNA with both P-site and A-site of 23S rRNA -In decoding (A1492, A1493) 55 A-minor INTERACTIONS Type I A-...
The structure shows how mitoribosomal proteins stabilise binding of mRNA and tRNA helping to align it in the decoding center, whereas the GDP-bound mS29 stabilizes intersubunit communication. Comparison between different states, with respect to tRNA position, allowed us to characterize a non-...