Structure of a group II intron in complex with its reverse transcriptase. Nat. Struct. Mol. Biol. 23, 549–557 (2016). Article CAS PubMed PubMed Central Google Scholar Li, S. et al. Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat. Struct. Mol....
Department of PhysicsBiopolymersLuo, L, M Jia, X Li. 2004. Protein structure preference, tRNA copy number, and mRNA stem/loop content. Biopolymers 74:432-447.Protein structure preference, tRNA copy number, and mRNA stem/loop content. Luo Liaofu,Jia Mengwen,Li Xiaoqin. Biopolymers . 2004...
It has long been appreciated that covalent modification of RNA is used by nature to expand the chemical repertoire of the four common nucleotides. tRNAs, in particular, are known to have prevalent modifications, and the roles of some of these have been elucidated1. For mRNAs and long non-codi...
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic compartments. In humans, approximately 60 proteins are i...
select article A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes Research articleOpen access A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadrup...
Gallie DR, Feder JN, Schimke RT, Walbot V: Functional analysis of the tobacco mosaic virus tRNA-like structure in cytoplasmic gene regulation. Nucl Acids Res 19: 5031–5036 (1991). PubMedCASGoogle Scholar Garcia A, Cuin JV, Pleij CWA: Differential response to frame shift signals in eukary...
The discovery of functional non-coding RNA sequences has led to an increasing interest in algorithms related to RNA analysis. Traditional sequence alignment algorithms, however, fail at computing reliable alignments of low-homology RNA sequences. The spatial conformation of RNA sequences largely determi...
The reduced sizes of the Cas7-11S and ΔINS-2 variants relative to the WT Cas7-11 enable packaging along with a crRNA expression cassette (either U6 or tRNA promoter) into single AAV vectors (Figure 6E). We tested Cas7-11S and ΔINS2 in HEK293FT cells via AAV8 delivery (Figure 6F...
Today, researchers know that cells contain a variety of forms of RNA—including messenger RNA (mRNA), transfer RNA (tRNA), andribosomal RNA(rRNA)—and each form is involved in different functions and activities. Messenger RNA is essentially a copy of a section of DNA and serves as a templat...
SLFN13′s N′-domain. Investigation of the structure and subsequent functional analysis reveals that SLFN13 is a novel tRNA/rRNA-targeting RNase with potent anti-HIV activity. These results expand our vision of translational control in high eukaryotes and functional mechanisms of the Schlafen family...