Structure of human chromosomes studied by atomic force microscopy.Part Ⅱ.Relationship between structure and cytogenetic bands. Tamayo J. J.Struct.Biol . 2003Javier;Tamayo.Structure of human chromosomes studied b
- december 2, 2012 imprint: academic press editor: jorge yunis language: english paperback isbn: 9780124316799 9 7 8 - 0 - 1 2 - 4 3 1 6 7 9 - 9 ebook isbn: 9780323154833 9 7 8 - 0 - 3 2 3 - 1 5 4 8 3 - 3 molecular structure of human chromosomes is an authoritative ...
Because the human active and inactive X chromosomes differ in transcriptional activity and replication, we looked for differences in their chromatin loop structures. Since the islands of CpG-rich DNA at the 5' ends of X-linked housekeeping genes are the regions where functional differences in DNA ...
The building block of chromatin is the nucleosome, which consists of a 147-base-pair DNA wrapped 1.65 times around an octamer of histones H2A, H2B, H3, and H46,7,8,9. However, to accommodate a two-meter-long DNA string into a human nucleus of around 10 μm in dimeter10, nucleosome...
Chromosomes Genome Genome Evolution Kinetochores Main Since the announcement of the sequencing of the human genome 20 years ago1,2, human chromosomes have remained unfinished owing to large regions of highly identical repeats clustered within centromeres, regions of segmental duplication, and the acrocent...
Human telomerase is a RNA–protein complex that extends the 3′ end of linear chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG1. Its activity is a determinant of cancer progression, stem cell renewal and cellular aging2–5. Telo
The segregation of four sets of genetic structures could be studied with the aid of repeated FISH and a large number of topographic types were observed. In all these experiments a non-random distribution of chromosomes into nuclear lobes was found. The painting of a single type of chromosome ...
Transglutaminase genes were thought to be scattered in the human genome, because the genes encoding TGK and factor XIII a-subunit have been mapped to chromosomes 14 (18) and 6 (25), respectively, whereas TGC and TGE have been mapped to chromosome 20 (14, 26), band 4.2 protein to ...
et al. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature 453, 948–951 (2008). CAS PubMed Google Scholar Denholtz, M. et al. Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in...
Little is known about the recent evolution of the Y chromosome because only the human Y chromosome has been fully sequenced. Prevailing theories hold that Y chromosomes evolve by gene loss, the pace of which slows over time, eventually leading to a paucity of genes, and stasis3,4. These ...