Human papillomavirus (HPV) is a significant contributor to the global cancer burden, and its carcinogenic activity is facilitated in part by the HPV early protein 6 (E6), which interacts with the E3-ligase E6AP, also known as UBE3A, to promote degradatio
Human Papillomavirus L1 protein makes up 80% of the viral capsid and self assembles in Virus-like Particles (VLP); these particles are immunogenic, generate type-specific antibodies and can induce very limited cross-reactivity among highly homologous HPV types. In addition to its structural ...
2.2. Structure of Viruses The infectious virus particle must be released from the host cell to infect other cells and individuals. Whether dsDNA, ssDNA, dsRNA, or ssRNA, the nucleic acid genome of the virus must be protected in the process. In the extracellular environment, the virus will be...
HPV is a double-stranded DNA virus with a circular genome of roughly 8 kbp. To date, well over 200 HPV types have been identified and fully sequenced10. The viral life cycle and how it causes disease have been most thoroughly studied in cervical dysplasia and carcinomas, where initial in...
Here we solve the crystal structure of a ternary complex comprising full-length human papilloma virus type 16 (HPV-16) E6, the LxxLL motif of E6AP and the core domain of p53. The LxxLL motif of E6AP renders the conformation of E6 competent for interaction with p53 by structuring a p53-...
DNA of human papillomavirus (HPV) types 16 and 18 has been found closely associated with human genital cancer, supporting the concept that members of this virus group are key factors in the aetiology of genital cancer. HPV 18 DNA sequences were also detected in cell lines derived from cervical...
These include: (1) validation and analysis of Zika virus (ZIKV)-human PPIs and discovery of estrogen receptor 1 (ESR1) as a major rheostat of viral replication; (2) analysis of human papilloma virus (HPV) determinants of oncogenicity and development of an interaction-based classifier of high...
The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role...
The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role...
The structure of BPV-1 is similar to that of other papilloma- viruses. It is a small icosahedral DNA virus with 72 capsomers whose genome consists molecule of molecular woefigahtdo(MubWle)-s5tr.a0nxd1ed06, circular DNA (ref. 17). The virions contain a major capsid protein of MW 53...