Human Papillomavirus L1 protein makes up 80% of the viral capsid and self assembles in Virus-like Particles (VLP); these particles are immunogenic, generate type-specific antibodies and can induce very limited cross-reactivity among highly homologous HPV types. In addition to its structural ...
Explore the function of human papillomaviruses. Learn the definition of human papillomavirus and understand the HPV virus structure. See when HPV...
Human papillomavirus (HPV) is a significant contributor to the global cancer burden, and its carcinogenic activity is facilitated in part by the HPV early protein 6 (E6), which interacts with the E3-ligase E6AP, also known as UBE3A, to promote degradatio
HPV is a double-stranded DNA virus with a circular genome of roughly 8 kbp. To date, well over 200 HPV types have been identified and fully sequenced10. The viral life cycle and how it causes disease have been most thoroughly studied in cervical dysplasia and carcinomas, where initial in...
The crystallographically determined structure of simian virus 40 shows that the 72 pentamers of viral protein VP1, which form the outer shell, have identical conformations except for the C-terminal arms of their subunits. Five arms emerge from each pentamer and insert into neighbouring pentamers. ...
DNA of human papillomavirus (HPV) types 16 and 18 has been found closely associated with human genital cancer, supporting the concept that members of this virus group are key factors in the aetiology of genital cancer. HPV 18 DNA sequences were also detected in cell lines derived from cervical...
ARTICLE https://doi.org/10.1038/s41467-020-18537-y OPEN Cryo-EM structure of the varicella-zoster virus A-capsid Junqing Sun1,2,9, Congcong Liu 3,9, Ruchao Peng 2,9, Fu-Kun Zhang4,9, Zhou Tong1,2,9, Sheng Liu2, Yi Shi 2,5, Zhennan Zhao2,5, Wen-Bo Zeng 6, George Fu ...
Virus attachment protein Virus taxonomy 2.1. Common Characteristics of Viruses As described in Chapter 1, “The World of Viruses” viruses were initially characterized as filterable agents capable of causing disease. Since that time, advances in microscopy and scientific techniques have led to a better...
(seeFoundations of Modern Cell Theory). In some cases, genomes of certain DNA viruses can also be maintained independently in host cells during latent viral infection. In these cases, these viruses are another form of extrachromosomal DNA. For example, the human papillomavirus (HPV) may be ...
6, which shows antibody-binding epitopes for two structures of HPV virus-like particles. Information from the primary reports for two PDB structures (PDB IDs 6bsp and 6bt3) of HPV16 with bound monoclonal antibodies U4 and V5, respectively, was used to define their epitopes [37], and then ...