Nav1.1–1.3 and Nav1.6 are the primary subtypes in the central nervous system, Nav1.7–1.9 mainly function in the peripheral nervous system, Nav1.5 is predominantly expressed in the heart, and Nav1.4 is the prevailing subtype in the skeletal muscle. More than 1,000 mutations in human Nav ...
but leave the molecular principles of its long-range energy coupling mechanism open to debate. Here, we describe the 3.0-Å resolution cryo-EM structure of complex I from mouse heart mitochondria with a substrate-like inhibitor, piericidin A, bound in the ubiquinone-binding active site. We com...
Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here, we report the crystal structure of SlpA, the main S-layer protein of the bacterial pathogen Clos
![](https://github.com/wusp/WuspViewPkg/blob/master/app/src/main/java/com/wusp/wuspviewpkg/Particle/particleheart.gif) First, it's just an example of combining particle system and other animation effects (ex. circle-expanding and heart-beat here). Second, the ParticleHeartView design idea...
Laboratory of Metabolism, National Heart Institute, Bethesda, Maryland 20014, USAJohn Wiley & Sons, LtdOrganic Mass SpectrometryP. Longevialle, D. Smith, A. Burlingame, H. Fales, R. Highet. High resolution mass spectrometry in molecular structure studies - V: The fragmentation of Amaryllis ...
Drug-induced abnormal heart rhythm known as Torsades de Pointes (TdP) is a potential lethal ventricular tachycardia found in many patients. Even newly rele... S Wacker,SY Noskov - 《Other》 被引量: 3发表: 2018年 QSPR study for prediction of boiling points of 2475 organic compounds using sto...
,... - 《European Heart Journal Cardiovascular Imaging》 被引量: 27发表: 2014年 Development of a test to identify bladder cancer in the urine of patients using mass spectroscopy and subcellular localization of the detected proteins The survival rate for bladder cancer is much better when the ...
Maximizing Business Potential: The Nexus of Website Design and Digital Marketing by: jinu1996 | last post by: In today's digital age, having a compelling online presence is paramount for businesses aiming to thrive in a competitive landscape. At the heart of this digital strategy lies an ...
Institute for Integrative Biology of the Cell, Université Paris-Saclay, Gif-sur-Yvette, France Brigitte Meunier Contributions A.M. designed and supervised the research. B.M. produced the yeast mutant strain. A.M.H. did all the protein work with contribution from Y.Z. A.C.-O. and S.A...
Pompe disease, a rare lysosomal storage disease caused by deficiency of the lysosomal acid α-glucosidase (GAA), is characterized by glycogen accumulation, triggering severe secondary cellular damage and resulting in progressive motor handicap and premat