Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control of insulin release from the pancreas. GLP-1 peptide agonists are efficacious drugs for the treatment of diabetes. To gain insight into the molecular mechanism of action of
Orskov C, Kofod H & Rabenhoj L (1992): Structure of human GLP-1(glucagon-like peptide-1) containing peptides. Diabetologia 35, [A109].Orskov C, Kofod H, Rabenhoj L. Structure of human GLP-1 (glucagon- like peptide-1) containing peptides. Diabetologia 1992;35:A109 (abstr)....
Vasoactive intestinal polypeptide receptor (VIP1R) is a widely expressed class B G protein-coupled receptor and a drug target for the treatment of neuronal, metabolic, and inflammatory diseases. However, our understanding of its mechanism of action and the potential of drug discovery targeting this ...
NMR solution structures were obtained for the most biologically relevant of these analogs. The results of this study indicated that the residues necessary for the biological activity of GLP-1 occupy approximately three equally-spaced regions of the peptide 3D structure, at the corners of an ...
Structure Therapeutics: Potential To Have Best-In-Class GLP-1 Agonist For Obesity PatientsTerry ChrisomalisTue, Oct. 22, 20243 Comments Structure Therapeutics: Pay Attention To This Overlooked Player In GLP-1 Weight Loss FieldEdmund InghamFri, Aug. 23, 20249 Comments Structure Therapeutics: Yet An...
D'Alessio, D.et al. Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system.Am. J. Physiol. Regul. Integr. Comp. Physiol.293, R2163–R2169 (2007). ...
And the results from IR, 77 Se NMR, 13 C NMR and Laser Raman spectra showed that the structure of activity center of selenium of SeGLP 1 might be O=Se=O,and CH 3 in -OCH 3 group of GLP 1 was substituted by selenium forming this structure. 展开 ...
Poster presentation (#754): A First-in-Human Single Ascending Dose Study of GSBR-1290, a Novel Small Molecule GLP-1 Receptor Agonist, in Healthy Volunteers Date:Sunday, June 25, 2023 Presentation Time:11:30 a.m. ...
Grant B, Greenwald I: The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Genet 1996, 143: 237–247. CAS Google Scholar Lüthy L, Grütter MG, Mittl PRE: The crystal structure of Helicobacter pylori cysteine-rich pro...
Another epigenetic mechanism that regulates HIF-1α activity is histone methylation/demethylation. The histone lysine methyltransferases, G9a and G9a-like protein (GLP), directly bind to HIF-1α and methylate HIF-1α at Lys674 but do not bind to HIF-2α. This modification reduces HIF-1α tr...