Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA Eva Nogales Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Eva Nogales Contributions D.C.R. and E.N. supervised the study. G.G. developed the...
Mulichak AM, Bonin CP, Reiter W-D, Garavito RM (2002) Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis thaliana: implications for ligand binding and specificity. Bio- chemistry 41:15578-15589Mulichak AM, Bonin CP, Reiter W-D, Garavito RM (2002) Structure of the MUR1 ...
The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha...
that the lipid membrane modulates the structure and dynamics of complex formation and provide a molecular explanation for the stronger interaction between GPCRs and G proteins in lipid bilayers. We propose an allosteric mechanism for GDP release, providing new insights into the activation of G ...
384-well black plates Greiner Bio-one GmbH Cat#781091 384-well white plates Greiner Bio-one GmbH Cat#781098 96-well black plates Greiner Bio-one GmbH Cat#655090 Meltilex Perkin Elmer Cat#1450-441 Filtermat A Perkin Elmer Cat#1450-421 Contact for Reagent and Resource Sharing Further informa...
Interest rates reflect the market's opinion of the current and future economy; they are influenced by inflation, world conflict, gross domestic product (GDP), and other macro-level events. We cannot ask what the term structure of interest rates is without understanding the interest rate. If a...
(culture-independent methods) in bees and to identify the functional characteristics of isolated strains. Samples were collected from the body, hive, honey, and beebread of bees from the generaTrigona,Scaptotrigona,Tetragona,Apis,Meliponas, andTetragoniscain the Pantanal, Amazon, and Cerrado ...
White1, Haijuan Du1, Nagarajan Vaidehi2 & Reinhard Grisshammer1 Many G protein-coupled receptors show constitutive activity, resulting in the production of a second messenger in the absence of an agonist; and naturally occurring constitutively active mutations in receptors have been ...
c-f, Comparison of the AHD of the canonical state NTS-NTSR1-Gi-cND (gold) with c, A crystal structure of GDP-Gi (blue; PDB 1GP2), d, A crystal structure of β2AR-Gs with nanobody Nb35 (AHD is dark red and Nb35 is green; PDB 3SN6), e, A cryo-EM structure of Rhodopsin...