2篓C4 The heavy chain is responsible for binding the neurotoxin to the receptor on neural membrane, 5,6 and the light chain is related to blockade of neurotransmitter release in presynaptic nerve endings. 7,8 The significance of the nontoxic component in the botulinum toxin molecule as an oral...
We determined amino acid sequences around cleavage sites in the loop region of botulinum NTs produced by type C strain Stockholm, type D strain CB16, and type F strain Oslo by analysis of the C-terminal sequence of Lc and the N-terminal sequence of Hc. Cleavage was found at one or two...
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryHambleton P. Botulinum toxin: structure and pharmacology. Eur Arch ...
In an advanced online publication of the journal Nature, the scientists show structurally how botulinum neurotoxin B (one of seven toxins the bacterium produces) recognizes receptors on the surface of human neurons. The structure reveals how these toxins work at the molecular level and provides a p...
1. Neurotoxin from Clostridium botulinum type B was purified to homogeneity by affinity and ion-exchange chromatography; specific neurotoxicity of this pro... DM Evans,RS Williams,CC Shone,... - 《Febs Journal》 被引量: 192发表: 1986年 A Dileucine in the Protease of Botulinum Toxin A Underli...
Determination of Volatile Phenol in Water by the Segment FlowInjection Analysis; 间隔流动注射法测定水中挥发酚方法概述 2. EthanolInjection Treatment of Simple Clinical Study of Breast Cysts; 无水乙醇注射法治疗单纯性乳腺囊肿的临床探讨 3. Objective To investigate the effect of botulinum toxin A(BTA) ...
Epsilon toxin (Etx), a potent pore forming toxin (PFT) produced by Clostridium perfringens, is responsible for the pathogenesis of enterotoxaemia of ruminants and has been suggested to play a role in multiple sclerosis in humans. Etx is a member of the aerolysin family of β-PFTs (aβ-PFTs...
Identification of gangliosides as inhibitors of ADP-ribosyltransferases of pertussis toxin and exoenzyme C3 from Clostridium botulinum We have previously reported the presence of an endogenous inhibitory activity in bovine brain for the ADP-ribosylation of GTP-binding proteins catalyzed by... M, Hara-...
Here, we present the crystal structures of botulinum neurotoxin type A catalytic domain in complex with four inhibitory substrate analog tetrapeptides, viz. RRGC, RRGL, RRGI, andRRGM at resolutions of 1.6-1.8 A. These structures show for the first time the interactions between the substrate ...
Botulinum and tetanus neurotoxins belong to a general group of bacterial protein toxins with a distinctive characteristics in terms of three structural domains with different complementary functions (Fig. 1). Other toxins of this group include cholera, diphtheria and Pseudomonas exotoxin A. These ...