1. On the basis of Thomson’s model of an atom, explain how the atom is neutral as a whole. Ans:As per Thomson’s model of an atom, the number of electrons and the number of protons are equal in an atom. Electrons are positively charged and protons are negatively charged, hence the...
We expect that this work will not only expand our fundamental understanding of this important class of materials but also provide the foundation for tailoring M/HEA properties through engineering lattice distortion and local chemical order.This is a preview of subscription content, access via your ...
RNA contains the nitrogenous bases adenine, guanine, cytosine and uracil, the latter of which is used in place of DNA’s thymine. RNA’s ribose sugar is a cyclical structure made up of five carbons and one oxygen atom each time. There are two carbons in the second carbon of r...
Structure-based drug design (SBDD) aims to design small-molecule ligands that bind with high affinity and specificity to pre-determined protein targets. Generative SBDD methods leverage structural data of drugs with their protein targets to propose new d
The difficulty of predicting the protein structures from a given amino acid sequence are due to the very large number of parameters involved. This is because the energy depends on the distance between each pair of atoms describing a given interaction. However, the most important problem is the ...
The peptide metabolism is activated by degradation of a wide range of bioactive peptides and therefore specific inhibitors of them have therapeutic values[6, 7]. One of the important classes of M13 family (of zinc peptidases; classification according to MEROPS database)[8] is “gluzincins” ...
Dewey), a segmental autoallohexaploid (2= 6= 42), is not only an important forage crop but also a valuable... RC Wang,SR Larson,KB Jensen,... - 《Genome》 被引量: 16发表: 2015年 Notes on the independence number in the Cartesian product of graphs We study the independence number ...
Evaluating protein structures in living cells remains a challenge. Here, we investigate Interleukin-4 receptor alpha (IL-4Rα) into which the non-canonical amino acid bicyclo[6.1.0]nonyne-lysine (BCNK) is incorporated by genetic code expansion. Bioorthog
atom RMSD = 0.6 Å, relative to 2.7 Å for the deactive state (PDB:6G72)) and exhibit all the hallmarks of it: the extended interface between NDUFA5 and NDUFA10 that defines the arrangement of the hydrophilic and membrane domains4; clear densities for the mobile loops in ...
E trp reflects the local conformational biases of secondary structure, which is local-sequence dependent. E sol stands for the solvation energy of protein, which reflects the hydrophobic effect of protein folding. We used a simple model based on Cα atom to derive the solvation energy by ...