a, 2D class averages of PIEZO1 proteoliposomes with a circular mask of 25 nm diameter, showing the cap domain located inside the vesicles. On the basis of the abruptly changed curvature, the red arrows might indicate the boundary between the PIEZO1-residing side and the opposite side lacki...
Medium- and high-entropy alloys (M/HEAs) mix several principal elements with near-equiatomic composition and represent a model-shift strategy for designing previously unknown materials in metallurgy1–8, catalysis9–14 and other fields15–18. One of the
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physics, chemistry, and biology have been connected by a web of causal explanation organized by induction-based theories that telescope into one another.…Thus, quantum theory underlies atomic physics, which is the foundation of reagent chemistry and its specialized offshoot biochemistry, which interlock...
Structure-invariant direct methods were used for primary atom site locations, and secondary atom site locations were found from the difference Fourier map. The software used to prepare the material for publication was Mercury 2.3 (Build RC4) and ORTEP-3 [20,21]. The complete set of structural ...
Crystal structure of neutral endopeptidase (pdb-id: 1DMT), the only well characterized member opened new door to acquire structural knowledge of several members of this class of the protein[30]. The three-dimensional structure of ECE-1 was also solved with the co-crystallized metalloprotease ...
and theoretical descriptors (e.g., atom number, molecular weight, atom-type count, etc.). These different types of molecular descriptors are widely used in molecular data mining, compound diversity analysis, and compound activity prediction. 2D-QSAR It is intuitive and concise to distinguish ...
a–c, Representative motion corrected cryo-EM micrographs (scale bar, 100 nm) of respective ligand bound GPCR heterotrimeric complex particles imaged at a nominal 45k x magnification and representative two-dimensional class averages. The experiment was repeated three times with similar result. The exa...
Nevertheless, the molecular architecture of the megaplex remains unknown. Here, we present its cryo-electron microscopy structure, which shows simultaneous engagement of human G protein and bovine β-arr to the core and phosphorylated tail, respectively, of a single active human chimeric β2-...
A waveguide structure formed with a three-dimensional (3D) photonic crystal is disclosed. The 3D photonic crystal comprises a periodic array of voids formed in a solid substrate. Th