Effect of cholesterol on the structure of a phospholipid bilayer. PNAS. 2009. 106, 3654-3658.de Meyer, F., & Smit, B. (2009). Effect of cholesterol on the structure of a phospholipid bilayer. Proceedings of the National Academy of Sciences, 106, 3654-3658....
Despite nearly 20 years of research, the role of the N-Lip and how it combines with the C-Lip to form a productive PAP enzyme has been unclear. Here we determined the first crystal structures of a lipin/Pah PAP fromTetrahymena thermophilathat revealed a two-domain architecture with a HAD-...
Potential candidate proteins include the Tryptophan rich antigen multi-gene family (TRAgs), which all share a Tryptophan-Threonine-rich domain of unknown function (PFAM ID PF12319, OrthoMCL ID OG6_145873), usually at their C-terminus. First identified in thePlasmodium yoelii(a species of parasit...
CHAPTER 10Biomembrane StructureA brief history of studies on the structrure of the plasmic membraneA. Conception: Plasma membrane(cell membrane), Intracellular membrane, Biomembrane.B. The history of study?Overton(1890s): Lipid nature of PM;E. Gorter F. Grendel 1925 bilayer lipid (On bimolecular...
Atomic Force Microscopy (AFM) is a powerful tool to study DNA structure at single molecule level. We here report a comprehensive analysis by AFM of DNA plasmid molecules with defined supercoiling degree, covering the full spectrum of biologically relevant topologies, under different observation ...
Ionic structure of phospholipid membranes, and binding of calcium ionsIonic structure of phospholipid membranes, and binding of calcium ionsdoi:10.1016/0005-2736(73)90073-4Radiotracer measurements of adsorption showed that the binding of Ca2+ with the phosphate groups of phosphatidylserine, phosphatidylet...
(Fig.3d). The cryo-EM map reveals an elongated density that extends toward the intracellular side, suggesting that a phospholipid sandwiched in the widening interface between p22 TM1 and NOX2 TM3 may stabilize the interface. The NOX2 residues Trp106, Ala109, and Ala113 face the modeled lipid...
After Hong gave a talk about the new technique at a conference, Henzler-Wildman suggested that they team up to study EmrE. Her lab has spent many years studying how EmrE transports a drug-like molecule, or ligand, across the phospholipid membrane. This ligand, known as F4-TPP+...
The conformation of the actual lipoprotein molecule is dependent upon how these lipotides fold upon one another which is not yet known. The model is based upon the ability of the helical peptide chains to bind to phospholipid, which in turn binds to cholesterol and its esters and to ...
R. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell 80, 929–938 (1995). Article CAS PubMed Google Scholar Perisic, O., Fong, S., Lynch, D. E., Bycroft, M. & Williams, R. L. Crystal structure of a calcium-phospholipid binding ...